Titanium Implant Surface Nanostructures for Protein Adherence
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current dental implants face challenges in achieving optimal protein adherence on their surface, which is crucial for osseointegration, and existing methods do not provide stable protein retention structures, especially when stored in dry environments.
Innovation Solution
A process involving acid-etching of a titanium or titanium alloy body, followed by storage in an aqueous solution to form nanostructures on the surface, which act as retention sites for proteins, maintaining hydrophilicity and enhancing cellular response.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the implant surface is made rough and hydrophilic to improve osseointegration, then protein adherence is improved, but the surface properties are lost when stored in dry environment
Solution Approach 1:
The patent applies preliminary action by forming nanostructures on the implant surface before implantation through acid-etching and storage in aqueous solution. These pre-formed nanostructures create retention sites that maintain protein adherence capability even after dry storage, eliminating the need to maintain hydrophilicity throughout the storage period while still achieving the desired biological response when implanted
Solution Approach 2:
The patent changes the surface parameters by transforming the smooth surface into a nanostructured surface through acid-etching. This parameter change creates a surface topology with nanoscale features that provide mechanical retention sites for proteins, fundamentally altering how the surface interacts with biological molecules without relying on hydrophilic chemical properties
2Ease of manufacture
If conventional storage methods are used for implants, then packaging is simplified, but protein retention structures are not stable in dry environment
Solution Approach 1:
The patent applies preliminary action by forming nanostructures on the implant surface before implantation through acid-etching and storage in aqueous solution. These pre-formed nanostructures create retention sites that maintain protein adherence capability even after dry storage, eliminating the need to maintain hydrophilicity throughout the storage period while still achieving the desired biological response when implanted
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process forms stable nanostructures that improve protein adherence and osseointegration, maintaining high hydrophilicity for up to two months, even in dry storage, facilitating simpler packaging and enhanced implant fixation in bone.
Implementation Method 1
storing the acid-etched basic body in an aqueous solution, whereby nanostructures are formed on the surface of the basic body
Implementation Method 2
ions and proteins will accumulate and adhere on the implant's surface, but without actually penetrating the material. This step is usually referred to as 'protein adsorption'
Implementation Method 3
The term 'hydrophilic' or 'hyperphilicity' as used in the context of the present invention refers to a contact angle of the hydrophilic surface area being less than 90°
Data Source
AI summary
Process for providing structures for an improved protein adherence on the surface of a body including the steps ofa) providing a basic body made of titanium or a titanium alloy,b) acid-etching the basic body,c) storing the acid-etched basic body in an aqueous solution, whereby nanostructures are formed on the surface of the basic body, andd) drying the basic body with the nanostructures formed on its surface.