Time-of-Flight Mass Spectrometer High-Voltage Pulse Generator Jitter Reduction

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Solution Overview

Problem

Conventional time-of-flight mass spectrometers face significant temporal discrepancies in high-voltage pulse generation due to temperature fluctuations and signal jitter, leading to reduced mass resolution in integrated mass spectra.

Innovation Solution

A time-of-flight mass spectrometer with a high-voltage pulse generator that includes a direct-current power supply, a switch circuit with semiconductor switching elements, and a drive signal generator that outputs primary and secondary drive signals with a delay, minimizing jitter by charging or discharging the switching element's control terminal to maintain precise timing for ion ejection.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a conventional high-voltage pulse generator is used, then the device complexity is reduced, but temporal fluctuations in high-voltage pulse generation increase, leading to reduced mass resolution

Engineering Contradiction:
Improvemass resolutionVSAvoiddrive signal generator complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The drive signal generator is segmented into multiple independent units: a primary drive signal generator and a secondary drive signal generator. The primary generator creates the initial drive signal, while the secondary generator creates a delayed version. This segmentation allows precise control over the timing and duration of the high-voltage pulse by independently adjusting each generator's parameters, thereby reducing temporal fluctuations and improving mass resolution.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The primary drive signal generator produces the drive signal in advance, and this signal is then fed into the secondary drive signal generator which adds a precise delay. This preliminary action ensures that the timing of the high-voltage pulse is pre-calculated and controlled before actual ion ejection, minimizing temporal jitter and improving measurement precision.

Inventive Principle:
Principle #10Preliminary action

2Reliability

If temperature compensation is implemented, then temporal stability improves, but device complexity increases

Engineering Contradiction:
Improvetemporal stabilityVSAvoidtemperature compensation system
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The dual-generator system inherently compensates for temporal instability through its own architecture. The primary and secondary generators work together to maintain consistent timing, with the secondary generator's delayed signal providing a reference that automatically corrects for drift without requiring external temperature sensors or compensation circuits.

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This configuration significantly reduces temporal fluctuations in high-voltage pulse generation, ensuring accurate timing alignment between ion ejection and measurement initiation, thereby enhancing mass-to-charge ratio accuracy and mass resolution.

Implementation Method 1

a switching element drive unit for charging or discharging a capacitance of a control terminal of the semiconductor switching element according to a drive signal

Methodology Applied
Scientific EffectCapacitance charging/discharging: Capacitance

Implementation Method 2

a pulse transformer 72 for transmitting a pulse signal from a control-system circuit to a power-system circuit while electrically insulating the control circuit that operates with a low voltage from the power circuit that operates with a high voltage

Methodology Applied
Scientific EffectElectromagnetic induction: Electromagnetic Induction

Implementation Method 3

an ion ejector for ejecting ions to be measured into a flight space by imparting acceleration energy to the ions by an effect of an electric field created by a voltage applied to an electrode

Methodology Applied
Scientific EffectElectric field acceleration: Electric Field

Data Source

PatentUS11443935B2Time-of-flight mass spectrometer
Publication Date: 2022.09.13 SHIMADZU CORP
  • US11443935B2 patent drawing
  • US11443935B2 patent drawing
  • US11443935B2 patent drawing

AI summary

An acceleration voltage generator is configured to cause a power MOSFET to turn on or off to switch a high direct-current voltage, so as to generate a high-voltage pulse for an ejection of ions from an ion ejector. A drive signal is used to cause the power MOSFET to turn on, and further includes a secondary drive signal to recharge a gate capacitance to cause the power MOSFET to stay in an on-state. In a drive signal generator, edge detection circuits generate an edge detection signal based on a start signal; selection circuits generate a primary drive signal by adjusting the edge detection signal in its signal width; and a secondary drive signal generator includes multiple circuit elements such as a semiconductor element, and generates the secondary drive signal.