Water-Soluble Tomato Extract Composition for Microbiota Modulation

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Solution Overview

Problem

Existing prebiotics lack clear demonstration of health benefits due to ambiguity in their definition, leading to misinformation and underutilization in treating conditions associated with gut microbiota imbalances.

Innovation Solution

Water-soluble tomato extracts (WSTE) are formulated to modulate the gut microbiota, inhibiting platelet aggregation and providing prebiotic activity, which can be combined with probiotics and further prebiotics to enhance health benefits.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional prebiotics are used, then gut microbiota modulation is attempted, but health benefits are not clearly demonstrated due to definition ambiguity

Engineering Contradiction:

Improvehealth benefit demonstrationVSAvoiddefinition clarity

Core Design Contradiction:

ReliabilityVSLoss of information

Solution Approach 1:

The patent changes the chemical composition parameters by using water-soluble tomato extract containing specific compounds (nucleosides, phenolic acids, flavonoids) with defined concentrations, transforming the vague prebiotic concept into a composition with measurable, demonstrable health benefits through controlled compositional parameters

Inventive Principle:

Principle #35Parameter changes

2Reliability

If water-soluble tomato extract is used to modulate gut microbiota, then health benefits are conferred, but the extract must be delivered specifically to the large intestine

Engineering Contradiction:

Improvehealth benefit confermentVSAvoiddelivery specificity

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent uses an intermediary delivery system (composition formulation with excipients) that facilitates the transport of water-soluble tomato extract to the large intestine, where it can effectively modulate gut microbiota without requiring direct manual intervention or complex administration procedures

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If WSTE is combined with probiotics and prebiotics, then health benefits are enhanced, but composition complexity increases

Engineering Contradiction:

Improvehealth benefit enhancementVSAvoidcomposition formulation

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges water-soluble tomato extract with probiotics and prebiotics in a single composition formulation, creating a synergistic combination that enhances health benefits while maintaining a unified product structure that simplifies administration compared to separate supplements

Inventive Principle:

Principle #5Merging (Combining)

Data Source

PatentUS20250319149A1Compositions for treating imbalances of the gut microbiota

Publication Date: 2025.10.16 PROVEXIS NATURAL PROD

AI summary

The present invention relates to uses of a tomato extract, and compositions containing tomato extracts that are formulated for delivery to the large intestine, for modulating the gut microbiota to confer a health benefit in a subject. The tomato extract can be used improve resistance to infection in the gut, reduce inflammation in the gut, treat or minimise inflammatory Bowel Disease or treat or minimise irritable bowel syndrome. The extracts may also be used to treat conditions associated with an imbalance of the gut microbiota such as anxiety, depression, Type II diabetes, non-alcoholic fatty liver disease, obesity or cognitive dysfunction.