Hybrid Tomato HM 8268 Breeding via Genome Editing

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Solution Overview

Problem

There is a need for stable, high-yielding tomato hybrids that excel in fruit production, appearance, and agronomic qualities, which existing breeding methods have not adequately addressed.

Innovation Solution

The development of a novel hybrid tomato plant designated HM 8268, along with methods for its propagation, breeding, and genetic modification using techniques such as backcrossing and genome editing to introduce desired traits like disease resistance and improved nutritional quality.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If conventional breeding methods are used to develop tomato hybrids, then fruit yield can be improved, but disease resistance and nutritional quality deteriorate

Engineering Contradiction:
Improvefruit yieldVSAvoiddisease resistance
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The patent applies local quality by introducing specific desirable traits (disease resistance, nutritional quality) into specific regions of the genome through targeted gene editing, while maintaining the overall high-yielding hybrid background. This allows simultaneous improvement of yield and resistance/quality traits without the trade-offs of conventional breeding.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The patent uses parameter changes by modifying specific genetic parameters (genes, loci) through editing techniques to alter plant traits. By changing specific genetic parameters rather than relying on random recombination, the invention achieves improved disease resistance and nutritional quality while maintaining high yield potential.

Inventive Principle:
Principle #35Parameter changes

2Productivity

If conventional breeding methods are used to develop tomato hybrids, then fruit yield can be improved, but fruit appearance and eating qualities deteriorate

Engineering Contradiction:
Improvefruit yieldVSAvoidfruit appearance and eating qualities
Core Design Contradiction:
ProductivityVSShape

Solution Approach 1:

The patent applies local quality by making targeted modifications to specific genes controlling fruit appearance and eating qualities, rather than relying on whole-genome recombination. This allows precise improvement of fruit traits while maintaining the high-yielding hybrid background.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The patent uses parameter changes by editing specific genetic parameters that control fruit appearance and eating qualities. This targeted approach allows simultaneous improvement of yield and fruit quality traits without the compromises inherent in conventional breeding.

Inventive Principle:
Principle #35Parameter changes

3Reliability

If genetic modification techniques are used to introduce desired traits, then disease resistance and nutritional quality are improved, but device complexity increases

Engineering Contradiction:
Improvedisease resistanceVSAvoidbreeding process complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent replaces the mechanical/conventional breeding system with genome editing technology. Instead of relying on traditional crossing and selection processes, the invention uses molecular-level gene editing to directly introduce desired traits, thereby reducing the complexity and time of the breeding process.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

4Reliability

If multiple breeding techniques are combined to improve multiple traits, then overall plant quality is improved, but manufacturing precision deteriorates

Engineering Contradiction:
Improveoverall plant qualityVSAvoidtrait consistency
Core Design Contradiction:
ReliabilityVSManufacturing precision

Solution Approach 1:

The patent uses parameter changes by precisely editing specific genetic parameters through genome editing technology. This allows controlled introduction of multiple traits with known effects, maintaining manufacturing precision through targeted modifications rather than random recombination.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent applies feedback by using molecular markers and genomic information to monitor and verify the introduction of desired traits. This feedback mechanism ensures precise control over trait consistency and allows for selection of plants with the intended genetic modifications.

Inventive Principle:
Principle #23Feedback

Data Source

PatentUS12075747B2Hybrid tomato plant named HM 8268
Publication Date: 2024.09.03 HM CLAUSE

AI summary

A hybrid tomato plant, designated HM 8268 is disclosed. The disclosure relates to the seeds of hybrid tomato designated HM 8268, to the plants and plant parts of hybrid tomato designated HIM 8268, and to methods for producing a tomato plant by crossing the hybrid tomato HM 8268 with itself or another tomato plant.