Tomato Parthenocarpy Through EMS Mutation Without Pleiotropic Effects

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Solution Overview

Problem

Existing methods for inducing parthenocarpy in tomatoes often result in undesirable pleiotropic effects such as malformed fruits, short anthers, abnormal stamens, and low fertility, and there is a need for a genetic source of fertilisation independent fruit formation without these negative side effects.

Innovation Solution

A tomato plant with a mutation induced by random genetic modification, specifically using ethyl methanesulfonate (EMS) mutagenesis, which allows for fertilisation independent fruit formation without pleiotropic effects, characterized by fruit size similar to fertilized fruits, seedlessness, and normal coloration and ripening.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If auxin or gibberellin is applied to unfertilised ovules to induce fruit formation, then fruit set is improved under suboptimal conditions, but fruit shape irregularities occur and production costs increase

Engineering Contradiction:
Improvefruit setVSAvoidfruit shape
Core Design Contradiction:
ReliabilityVSManufacturing precision

Solution Approach 1:

The invention extracts and isolates the specific genetic mechanism (parthenocarpy mutation) that enables fruit formation without fertilisation, separating this desired function from the harmful side effects of hormone application. The mutation specifically affects the fruit development pathway while leaving other plant functions intact, thus achieving reliable fruit set without shape irregularities.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The invention changes the genetic parameter of the plant through mutation, creating a permanent genetic alteration that enables parthenocarpy. This genetic parameter change replaces the need for external hormone application, providing consistent fruit set reliability while maintaining normal fruit shape development through the plant's endogenous regulatory systems.

Inventive Principle:
Principle #35Parameter changes

2Reliability

If existing parthenocarpic mutants are used, then fertilisation independent fruit formation is achieved, but pleiotropic effects such as malformed fruits, short anthers, abnormal stamens, and low fertility occur

Engineering Contradiction:
Improvefruit formationVSAvoidpleiotropic effects
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The invention converts the random mutagenesis process, which typically produces harmful pleiotropic effects, into a beneficial outcome by systematically screening for rare mutations that specifically affect only the fruit formation pathway. The random mutagenesis with EMS creates genetic variation, and the selection process identifies the beneficial parthenocarpic mutation while eliminating lines with harmful pleiotropic effects.

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The invention achieves local quality by creating a mutation that specifically affects the fruit development pathway (parthenocarpy) while leaving other plant functions (anther development, stamen function, fertility) unchanged. This localized genetic effect is achieved through random mutagenesis followed by selective screening for mutations that confer parthenocarpy without accompanying pleiotropic effects.

Inventive Principle:
Principle #3Local quality

3Adaptability or versatility

If random mutagenesis is performed to find parthenocarpic mutants, then fertilisation independent fruit formation can be obtained, but extensive screening is required to eliminate pleiotropic effects

Engineering Contradiction:
Improvefruit formation capabilityVSAvoidscreening time
Core Design Contradiction:
Adaptability or versatilityVSLoss of time

Solution Approach 1:

The invention applies preliminary action by using random mutagenesis with EMS to create a population of mutated plants, then performing preliminary screening to identify and eliminate lines with obvious pleiotropic effects before final selection. This preliminary filtering reduces the workload of extensive screening while ensuring that only clean parthenocarpic mutants are selected for further development.

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method produces tomatoes with fruits that are seedless, similar in size and ripening to fertilized fruits, without any negative pleiotropic effects, achieved through unbiased genetic screening and phenotypic selection.

Implementation Method 1

A tomato plant with a mutation induced by random genetic modification, specifically using ethyl methanesulfonate (EMS) mutagenesis

Methodology Applied
Scientific EffectChemical mutagenesis:

Data Source

PatentEP4233529B1Fertilisation independent fruit formation in tomato
Publication Date: 2025.08.27 RIJK ZWAAN ZAADTEELT & ZAADHANDEL BV
  • EP4233529B1 patent drawingFigure 1A~1B
  • EP4233529B1 patent drawingFigure 2
  • EP4233529B1 patent drawingFigure 3

AI summary

The present invention relates to a tomato plant comprising the trait fertilization independent fruit formation without negative pleiotropic effects selected from malformed fruits, short anthers, abnormal stamens, and low fertility, wherein the fruits that are formed independently from fertilization have a size similar to the size of fruits formed after fertilization, have jelly in the fruit and a complete absence of seeds, and have a coloration and ripening process comparable to tomato fruits that are formed after fertilization. The present invention further relates to a tomato plant as described above, wherein this trait is obtained from a plant representative seed of which was deposited with the NCIMB under accession number NCIMB 41269. Finally, the present invention relates to various forms of propagation material of the tomato plant comprising the traits described above.