Tomato Powder Composition with Olive Polyphenols for Prostate Cancer Prevention
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Solution Overview
Problem
Current tomato-based compositions for prostate cancer prevention and treatment do not adequately reduce serum levels of proangiogenic and pro-inflammatory mediators VEGF and IL6, which are crucial in carcinogenesis and tumor progression.
Innovation Solution
A composition comprising tomato powder enriched with carotenoids, flavonoids, and ketosamines, combined with a polyphenolic extract derived from olive oil and/or olive oil waste water, in a specific weight ratio, to effectively reduce VEGF and IL6 serum levels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If tomato powder alone is used for prostate cancer prevention, then lycopene content is sufficient, but the reduction of VEGF and IL6 serum levels is inadequate
Solution Approach 1:
The patent combines tomato powder with polyphenolic extract from olive mill wastewater to create a composite composition. This composite approach integrates multiple bioactive compounds (lycopene, other carotenoids, polyphenols, and ketosamines) that work synergistically to reduce VEGF and IL6 serum levels more effectively than lycopene alone, while maintaining adequate lycopene content for prostate cancer prevention.
2Quantity of substance
If processed tomato products are consumed, then absorption of lycopene improves due to cis isomers, but thermal degradation reduces antioxidant content
Solution Approach 1:
The patent utilizes controlled thermal processing parameters to induce isomerization of lycopene from all-trans to cis forms, which enhances absorption. Simultaneously, the processing conditions are optimized to minimize degradation of other antioxidants. The combination with polyphenolic extract compensates for any antioxidant loss during processing, maintaining overall antioxidant capacity while improving lycopene bioavailability.
3Reliability
If tomato powder is combined with polyphenolic extract, then anti-inflammatory and anti-cancer effects are enhanced, but composition complexity increases
Solution Approach 1:
The patent utilizes olive mill wastewater, which would otherwise be a waste product, as the source of polyphenolic extract. This approach converts a disposal problem into a valuable ingredient source, reducing the need for separate extraction processes and simplifying the overall supply chain. The composition leverages naturally occurring compounds that work synergistically without requiring complex formulation procedures.
Data Source
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AI summary
The present invention relates to a tomato powder based composition, methods for preparing it and its use.