Tooth Mineralization Solution with NCP Analogue for Rapid Dentin Tubule Occlusion
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Solution Overview
Problem
Current tooth mineralization solutions face challenges such as long treatment times, unstable mineralization effects, continuous supply issues of calcium and phosphate sources, and difficulties in long-term storage, which affect the efficacy of dentin remineralization and tubule occlusion.
Innovation Solution
A tooth mineralization solution comprising a reagent A with NCPs analogue and calcium salt, and a phosphate solution, where the dosage volume ratio and molar concentration of calcium to phosphate are optimized to enhance calcium ion penetration and hydroxyapatite formation, along with additional components like fluoride, sweeteners, humectants, and antibacterial agents for improved stability and bioactivity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional tooth mineralization solutions (fluoride, bioactive glass, adhesive) are used, then dentin tubule occlusion is achieved, but the mineralization effect is unstable and treatment time is long
Solution Approach 1:
The patent changes the chemical parameters of the mineralization solution by using a mixed system of calcium chloride and disodium phosphate at optimized molar ratios (1:0.8 to 1:1.2), with pH controlled at 6.0-8.0. This parameter optimization enables rapid formation of amorphous calcium phosphate that converts to hydroxyapatite, achieving stable mineralization in just 5 minutes compared to conventional methods requiring hours or days.
Solution Approach 2:
The patent creates a composite mineralization solution combining calcium chloride, disodium phosphate, and NCPs (non-collagenous proteins) in specific proportions. This composite formulation synergistically promotes rapid precipitation of amorphous calcium phosphate that transforms into hydroxyapatite crystals, providing both rapid action and stable, long-lasting mineralization effects that single-component solutions cannot achieve.
2Productivity
If amorphous calcium phosphate mineralization solution with high calcium concentration (>50 mmol) is used, then calcium and phosphate supply rate increases, but calcium phosphate salt precipitation occurs rapidly reducing storage stability
Solution Approach 1:
The patent optimizes calcium concentration to 10-50 mmol (within the stable range) and adjusts pH to 6.0-8.0, preventing premature precipitation while maintaining high mineralization activity. The mixed calcium phosphate system with controlled molar ratio ensures rapid in-situ formation of amorphous calcium phosphate that converts to hydroxyapatite, achieving high productivity without sacrificing storage stability.
Solution Approach 2:
The patent introduces NCPs (non-collagenous proteins) as intermediaries that facilitate the controlled transformation from amorphous calcium phosphate to hydroxyapatite crystals. These proteins act as templates and stabilizers, enabling rapid mineralization while preventing uncontrolled precipitation, thus resolving the contradiction between high mineralization rate and solution stability.
3Reliability
If NCPs analogue-stabilized amorphous calcium phosphate solution is used, then mineralization occurs, but calcium and phosphate ions are slowly replenished requiring long treatment time
Solution Approach 1:
The patent employs a two-stage periodic action: first, rapid precipitation of amorphous calcium phosphate from the mixed calcium phosphate solution (providing immediate mineral supply), followed by in-situ transformation to hydroxyapatite crystals (providing stable long-term mineralization). This periodic process delivers both rapid initial mineral deposition and sustained long-term stability, eliminating the slow replenishment issue of conventional single-stage methods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides rapid and deep dentin tubule occlusion, stable long-term storage, and effective collagen mineralization, overcoming previous limitations of shallow sealing and high preparation costs, while ensuring biological safety and broad market applicability.
Implementation Method 1
the NCPs analogue is one or more of a group consisting of polyelectrolytes such as polyaspartic acid, polyacrylic acid, polyvinylphosphonic acid, polyglutamic acid, carboxymethyl chitosan, sodium trimetaphosphate and sodium tripolyphosphate
Implementation Method 2
as the concentrations of calcium and phosphate ions increase, the calcium phosphate salt precipitation will be generated rapidly
Implementation Method 3
the prepared calcium-phosphate mixed mineralization solutions or amorphous calcium phosphates are prone to phase transition and then precipitate as hydroxyapatite crystals
Implementation Method 4
After ACP from mineralization solution enters the collagen, it is converted into hydroxyapatite to achieve intrafibrillar mineralization
Implementation Method 5
an appropriate amount of fluoride... can also be added to the reagent A or reagent B to increase the anti-caries performance of the material
Data Source
AI summary
Disclosure is a tooth mineralization solution and a mineralization method thereof. The tooth mineralization solution can be used to mineralize collagen and teeth. The mineralization solution component of the present application comprises two parts, namely, reagent A containing non-collagenous protein analogue and calcium salt, and reagent B is phosphate solution. The mineralization method of the tooth mineralization solution of the present application comprises the steps of first applying the reagent A to the surface of tooth, and then applying the reagent B to achieve tooth mineralization. In addition, the mineralization solution of the present application can also be used to achieve biomimetic mineralization of collagen by the same method, comprising the steps of soaking or floating single-layer reconstituted collagen fibril, collagen gel or collagen sponge in the reagent A, and then soaking or floating in the reagent B to achieve biomimetic mineralization.