Top-View Sample Color Inspection Past Barcode Obstruction

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Solution Overview

Problem

Existing laboratory automation systems face difficulties in accurately determining the quality of biological samples due to obstructed views caused by barcode labels, which can affect the accuracy of analytical results.

Innovation Solution

A method involving a data processing system that captures and processes a color image of the biological sample from a top view perspective, determining sample quality by comparing the sample color with reference colors, and optionally using machine learning to enhance accuracy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If barcode labels are adhered to the container for identification and handling, then the container can be properly identified and tracked, but the view of the biological sample is obstructed, affecting the accuracy of sample quality determination

Engineering Contradiction:
Improvesample quality determination accuracyVSAvoidview obstruction by barcode label
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent transitions from side-view imaging to top-view imaging of the container. By positioning the camera above the container and capturing an image from the top, the barcode label on the side of the container no longer obstructs the view of the biological sample. This dimensional change in imaging perspective resolves the contradiction between having barcode labels for identification and maintaining clear visibility of the sample for quality assessment.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

2Measurement precision

If automated visual inspection is performed from the side view to determine sample quality, then the method can be implemented with existing equipment, but the barcode label obstructs the view and reduces measurement precision

Engineering Contradiction:
Improvesample quality assessment accuracyVSAvoidimaging system complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent employs a top-view imaging approach, positioning the camera above the container to capture the biological sample from above. This simple geometric change in imaging perspective provides a clear view of the sample without requiring complex image processing algorithms or additional hardware components, thus maintaining low device complexity while significantly improving measurement precision.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

3Reliability

If the container is capped to protect the biological sample, then the sample is protected from contamination, but the view of the sample is completely blocked, preventing quality determination

Engineering Contradiction:
Improvesample integrity protectionVSAvoidsample visibility for quality inspection
Core Design Contradiction:
ReliabilityVSDifficulty of detecting and measuring

Solution Approach 1:

The patent performs the quality inspection action before the container is capped. By capturing an image of the biological sample from the top view while the container is still uncapped, the system determines sample quality integrity before closure. This preliminary action allows the container to be capped subsequently without compromising the ability to assess sample quality, thus resolving the contradiction between sample protection and detectability.

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables accurate determination of sample quality by overcoming view obstructions from barcode labels, ensuring reliable analytical results.

Implementation Method 1

a camera apparatus (14), configured to obtain a color image (9) showing at least part of a surface (6) of the biological sample (2) from a top view perspective on the container (1)

Methodology Applied
Scientific EffectLight reflection: Reflection

Implementation Method 2

determining, by a data processing apparatus (11), at least one sample color of the biological sample (2) based on the color image (9)

Methodology Applied
Scientific EffectColor image processing: Image Processing

Data Source

PatentEP4650752A1Method for determining a sample quality of a biological sample inside a container
Publication Date: 2025.11.19 BECKMAN COULTER INC
  • EP4650752A1 patent drawingFigure 1~2
  • EP4650752A1 patent drawingFigure 3a~4
  • EP4650752A1 patent drawing

AI summary

The disclosure relates to a method (100) for determining a sample quality of a biological sample (2) inside an uncapped container (1), the method (100) comprising: - determining, by a data processing system (11), at least one sample color of the biological sample (2) based on a color image (9) showing at least part of a surface (6) of the biological sample (2) from a top view perspective on the container (1); and - determining, by the data processing system (11), the sample quality of the biological sample (2) based on a comparison of the determined at least one sample color with at least one reference color.