Topical Anticholinergic Formulation With Phased Hyperhidrosis Dosing

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Solution Overview

Problem

Existing treatments for severe hyperhidrosis, such as anticholinergic compounds, suffer from instability, inadequate cosmetic acceptance, systemic side effects, and limited efficacy, necessitating daily application to maintain effectiveness.

Innovation Solution

A topical formulation with a specific administration regimen divided into an initial phase of 1-7 times per week for up to six months, followed by a maintenance phase of 1-5 times per week, using a reduced amount of anticholinergic compounds like glycopyrronium salts, to maintain efficacy while reducing side effects and improving compliance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If anticholinergic compounds are applied daily to maintain therapeutic efficacy, then sweat production reduction is maintained, but patient compliance deteriorates due to frequent application requirements and systemic side effects

Engineering Contradiction:

Improvetherapeutic efficacyVSAvoidpatient compliance

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent implements a pulsed application regimen where the anticholinergic compound is applied intermittently (e.g., once or twice weekly) rather than daily, while maintaining therapeutic efficacy through optimized formulation delivery systems that sustain active ingredient release over extended periods

Inventive Principle:

Principle #19Periodic action

Solution Approach 2:

The formulation is designed to self-regulate drug delivery through controlled release mechanisms, reducing the need for frequent patient intervention and application while maintaining consistent therapeutic levels at the target site

Inventive Principle:

Principle #25Self-service

2Reliability

If aluminum containing antiperspirants are used to treat excessive sweating, then sweat production is reduced, but textiles are stained or discolored and environmental concerns increase

Engineering Contradiction:

Improvesweat reduction efficacyVSAvoidtextile discoloration and environmental pollution

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent extracts and eliminates aluminum compounds from the antiperspirant formulation, replacing them with alternative active ingredients that achieve sweat reduction through different mechanisms without the harmful side effects of aluminum accumulation and textile discoloration

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The invention changes the chemical composition parameters of the active ingredient from aluminum-based compounds to alternative substances (such as magnesium chloride or other non-aluminum minerals), fundamentally altering how sweat reduction is achieved while avoiding the harmful effects associated with aluminum

Inventive Principle:

Principle #35Parameter changes

3Reliability

If surgical removal of sweat glands is performed to treat severe hyperhidrosis, then excessive sweating is eliminated, but serious side effects and surgical risks occur

Engineering Contradiction:

Improvesweat reduction efficacyVSAvoidsurgical side effects and risks

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the mechanical/surgical approach of physically removing sweat glands with a chemical/pharmacological approach using topically applied anticholinergic compounds that block sweat gland activity reversibly, achieving similar therapeutic outcomes without surgical intervention, anesthesia risks, permanent damage, or long-term complications

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

4Object-affected harmful factors

If the amount of active ingredient is reduced to minimize side effects, then systemic exposure decreases, but therapeutic efficacy in severe hyperhidrosis is compromised

Engineering Contradiction:

Improvesystemic side effectsVSAvoidtherapeutic efficacy

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent enhances local concentration of the active ingredient at the application site through optimized formulation vehicles, penetration enhancers, and targeted delivery systems, allowing low systemic doses to achieve high local efficacy that treats severe hyperhidrosis while minimizing systemic absorption and associated side effects

Inventive Principle:

Principle #3Local quality

Data Source

PatentUS20250255794A1Topical formulation of an anticholinergic compound for treating severe hyperhidrosis and excessive sweating

Publication Date: 2025.08.14 DR AUGUST WOLFF GMBH & CO KG ARZNEIMITTEL

AI summary

The present invention relates to a topical formulation comprising at least one anticholinergic compound for use in treating patients suffering from severe hyperhidrosis, wherein administration of the formulation to the patient comprises: a) an initial phase with a topical administration of a predetermined amount of the formulation 5 to 7 times per week for a total time period of less than six months: followed by b) a maintenance phase with a topical administration of the same amount of the formulation 1 to less than 5 times per week.