Topical Base Composition for Deep Skin Penetration
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Solution Overview
Problem
Current topical skin compositions with hydrocortisone lack penetration deep into the skin, are messy, inconvenient, and ineffective for treating large or small skin areas, with issues such as greasiness, poor cosmetic elegance, and limited applicability, leading to poor patient compliance and limited efficacy for conditions like psoriasis and eczema.
Innovation Solution
A novel topical base composition combining FANCOL VB, Natunola Castor 1023, Finsolv TN, and bees wax, in specific weight percentages, forming a solid or semi-solid carrier vehicle that penetrates multiple skin layers, prevents transepidermal water loss, has a pleasant feel and taste, and is applicable in various sizes and shapes, maintaining consistency across temperatures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional topical compositions are used, then they can be applied to the skin, but they do not penetrate deep into the skin layers, limiting efficacy for deep skin conditions
Solution Approach 1:
The patent modifies the physical and chemical parameters of the topical composition by incorporating specific penetration enhancers and optimizing the vehicle formulation to enable deep skin penetration. This resolves the contradiction by changing the composition parameters to achieve both surface application and deep tissue penetration simultaneously.
Solution Approach 2:
The patent uses a composite formulation combining multiple ingredients including penetration enhancers, active agents, and specialized vehicles. This composite approach enables the composition to penetrate deep into skin layers while maintaining therapeutic efficacy, resolving the contradiction between application capability and penetration depth.
2Reliability
If greasy topical compositions are used to treat skin conditions, then they may have some therapeutic effect, but they are messy and inconvenient, leading to poor patient compliance
Solution Approach 1:
The patent changes the physical state and texture parameters of the topical composition by using specialized vehicles and formulation techniques. This produces a non-greasy, easy-to-apply formulation that maintains therapeutic effectiveness while significantly improving patient compliance through pleasant application characteristics.
Solution Approach 2:
The patent optimizes the local quality of the formulation by incorporating ingredients that provide targeted therapeutic action without the unwanted greasy properties. This allows the composition to deliver effective treatment while having desirable application characteristics that improve patient compliance.
3Reliability
If topical compositions are designed for specific application areas, then they can be effective for those conditions, but they are limited in applicability to different skin areas and conditions
Solution Approach 1:
The patent creates a universal topical composition that can be effectively applied to various skin areas and conditions. The formulation is designed with broad-spectrum activity and adaptable properties, allowing it to treat different skin conditions across various body surfaces, thus resolving the contradiction between specificity and versatility.
4Ease of manufacture
If topical compositions do not maintain consistency across temperatures, then they may be easier to manufacture, but they become messy and ineffective when exposed to temperature variations
Solution Approach 1:
The patent optimizes the formulation parameters to ensure thermal stability. By carefully selecting ingredients and optimizing the vehicle composition, the patent achieves a formulation that maintains its physical and chemical stability across a wide temperature range, resolving the contradiction between manufacturing ease and temperature stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively repairs and heals a wide range of skin disorders, including eczema and psoriasis, with improved patient compliance and cosmetic appeal, providing 100% improvement in skin conditions like hand dermatitis and seborrheic dermatitis, while being easy to administer and maintain.
Implementation Method 1
They penetrate one or more layers of, and tissues in, the skin
Implementation Method 2
penetrate one or more layers of, and tissues in, the skin
Implementation Method 3
prevents transepidermal water loss
Data Source
AI summary
The invention provides skin-protecting and penetrating, easy-to-administer base and active agent-containing compositions, such as those including hydrocortisone, for treating the skin of mammals for different dermatologic disorders. This is effected by topically administering effective amounts of the compositions thereto in forms that address the skin and mucosa of the mouth and lips, and the rest of the body. Additionally, an optional flavoring addition to these products affords significantly better tasting, and less bitter, compositions, allowing a more pleasant experience and better compliance by patients. The compositions include a unique formulation of FANCOL VB, Natunola Castor 1023, Finsolv TN, bees wax and, optionally, one or a plurality of plant or plant seed oils, fatty alcohols, fats and flavorings, in desirable weight percents thereof, in various forms, and preferably in a form of a solid roll-on stick in a variety of sizes and of a jar or pot.