Topical Buffering Formulations for Local Tumor pH Modulation
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Solution Overview
Problem
Current oral and intravenous administration of pH modulating buffers for cancer and gout are limited by intolerance and side effects, and there is a lack of effective topical and transdermal formulations for inhibiting metastasis, tumor growth, and other diseases.
Innovation Solution
Administering buffering agents topically and/or transdermally to modulate the pH of tissues proximal to tumors or affected areas, using formulations that include chemical permeation enhancers and cell penetrating peptides for enhanced skin penetration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If oral or intravenous buffering agents are administered to modulate pH for cancer treatment, then the therapeutic effect on tumor growth and metastasis is improved, but patient intolerance and side effects increase
Solution Approach 1:
The invention extracts the buffering agent from systemic circulation and delivers it directly to the tumor site through topical or transdermal application, eliminating the need for oral or intravenous administration and thereby avoiding systemic side effects while maintaining local therapeutic efficacy
Solution Approach 2:
The invention uses permeation enhancers and formulation vehicles as intermediaries to facilitate the transdermal delivery of buffering agents, enabling the agent to penetrate the skin barrier and reach the tumor microenvironment without requiring systemic administration
2Object-affected harmful factors
If topical formulations are used to deliver buffering agents to tumors, then side effects are reduced, but skin penetration and delivery efficacy are insufficient
Solution Approach 1:
The invention incorporates permeation enhancers such as fatty acids, alcohols, and surfactants as intermediaries that temporarily disrupt the skin barrier to facilitate the transport of buffering agents through the stratum corneum and into the tumor tissue
Solution Approach 2:
The invention modifies the physical and chemical parameters of the formulation including pH, viscosity, and composition to optimize skin penetration and ensure adequate delivery of the buffering agent to the target site
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Inhibits tumor growth, prevents metastasis, and treats gout by altering the local pH, reducing side effects and improving treatment efficacy.
Implementation Method 1
formulations that include chemical permeation enhancers and cell penetrating peptides for enhanced skin penetration
Implementation Method 2
Administering buffering agents topically and/or transdermally to modulate the pH of tissues proximal to tumors or affected areas
Data Source
AI summary
Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.