Topical Combination Formulations for Mixed Skin and Nail Infections
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Solution Overview
Problem
Existing treatments for skin and nail conditions often overlook secondary infections and are inadequate for complex combinations of infections, particularly bacterial and fungal infections, due to the sparing use of antibacterial agents to prevent resistance.
Innovation Solution
Compositions comprising a combination of antibacterials, antifungals, and anti-inflammatories, such as mupirocin, terbinafine, clotrimazole, and hydrocortisone, are formulated for topical application to effectively treat complex skin and nail infections.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If antibacterial agents are used to treat bacterial infections, then treatment effectiveness is improved, but antibacterial resistance develops
Solution Approach 1:
The patent combines multiple antibacterial agents with different mechanisms of action (e.g., mupirocin targeting protein synthesis, polymyxin B targeting cell membranes) in a single topical formulation. This combination approach maintains treatment effectiveness while reducing resistance development because the pathogens would need to develop multiple simultaneous resistance mechanisms
Solution Approach 2:
The formulation uses composite active ingredients including both antibacterial and antifungal agents with distinct chemical structures and mechanisms. This composite approach allows treatment of mixed infections while the diverse mechanisms reduce the likelihood of resistance development to all components
2Ease of operation
If standard treatments focus on primary infection only, then treatment simplicity is maintained, but complex infections with secondary infections are inadequately treated
Solution Approach 1:
The topical formulation is designed with multi-functional active ingredients that simultaneously address bacterial infections, fungal infections, and inflammatory responses. A single application provides broad-spectrum coverage for complex infections while maintaining ease of use
Solution Approach 2:
Multiple therapeutic agents targeting different pathogens and inflammatory pathways are merged into one formulation, allowing treatment of complex mixed infections with a single product rather than requiring multiple separate treatments
3Adaptability or versatility
If multiple antibacterial agents are combined, then coverage of resistant bacteria is improved, but formulation complexity increases
Solution Approach 1:
The formulation employs composite materials science to compatibilize multiple antibacterial agents with different chemical properties (e.g., hydrophilic mupirocin and lipophilic polymyxin B) in a single stable base, achieving broad coverage without proportionally increasing formulation complexity
Data Source
AI summary
Described herein are topical compositions containing one or more of an antibacterial, an antifungal, and an anti-inflammatory, for use in supporting the health of a subject, including preventing or treating a fungal infection, a yeast infection, a bacterial infection, inflammation, or any combination thereof.