Topical Composition for Skin Aging via Adipocyte Stimulation

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Solution Overview

Problem

Current cosmetic products and medical procedures for addressing skin aging, particularly on the face and vulvar areas, are either ineffective or invasive, and there is a need for alternative compositions and methods that can topically improve skin fullness and appearance without the costs and discomfort of surgical interventions.

Innovation Solution

A topical composition comprising L-ornithine, Spondias mombin pulp extract, Mangifera indica (Mango) pulp extract, and Musa sapientum (banana) pulp extract, which synergistically increases adipogenesis and lipogenesis, enhancing adipocyte size and lipid production to plump and firm the skin, thereby reducing signs of aging.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Strength

If cosmetic products use retinoids, hydroxy acids and exfoliants to encourage skin rejuvenation, then skin firmness and appearance are improved, but the products cause inflammation and irritation to the skin

Engineering Contradiction:

Improveskin firmnessVSAvoidinflammation and irritation

Core Design Contradiction:

StrengthVSObject-affected harmful factors

Solution Approach 1:

The patent changes the active ingredients from traditional irritating substances (retinoids, hydroxy acids) to plant-derived extracts (pomegranate, green tea, rosehip) that provide similar skin rejuvenation benefits without causing inflammation. This parameter change in chemical composition resolves the contradiction between achieving skin firmness and avoiding irritation.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent combines multiple plant extracts (pomegranate, green tea, rosehip) with vitamin E and other beneficial compounds to create a composite formulation that provides synergistic effects for skin rejuvenation while maintaining gentleness and avoiding the harmful side effects of single-ingredient traditional products.

Inventive Principle:

Principle #40Composite materials

2Strength

If medical procedures such as dermal injections and reconstructive surgery are used to reduce signs of aging, then skin fullness and appearance are significantly improved, but the procedures are costly, painful and invasive

Engineering Contradiction:

Improveskin fullnessVSAvoidinvasiveness and cost

Core Design Contradiction:

StrengthVSEase of operation

Solution Approach 1:

The patent replaces invasive mechanical procedures (surgery, injections) with a topical chemical formulation that delivers active ingredients through the skin. This substitution eliminates the need for painful, costly medical interventions while achieving similar skin rejuvenation effects through transdermal absorption of plant extracts and growth factors.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent offers an affordable, non-invasive topical cream alternative to expensive medical procedures. The composition uses naturally derived, cost-effective plant extracts that can be applied repeatedly without the high costs and risks associated with surgical interventions, making skin rejuvenation accessible and comfortable for consumers.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Volume of stationary object

If conventional cosmetic ingredients claim to enhance adipogenesis, then skin fullness may be improved, but the potency is variable and effectiveness is not proven

Engineering Contradiction:

Improveadipocyte sizeVSAvoidpotency consistency

Core Design Contradiction:

Volume of stationary objectVSReliability

Solution Approach 1:

The patent combines multiple compounds known to support adipogenesis (pomegranate extract with punicalagin, green tea extract with EGCG, rosehip extract with vitamin C, and added vitamin E) to create a synergistic formulation. This composite approach ensures consistent and reliable enhancement of adipocyte size and function, overcoming the variability issue of single-ingredient products.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent incorporates ingredients that support healthy fat cell function and regeneration, creating a feedback mechanism where the composition promotes conditions that enhance its own effectiveness. The plant extracts and vitamins work together to stimulate adipogenesis and maintain skin volume, providing reliable and measurable results.

Inventive Principle:

Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively increases adipocyte number and size, improving skin fullness, firmness, and resiliency, providing a more youthful appearance without the need for invasive procedures, as demonstrated by increased cell survival, adipogenesis, and lipogenesis in treated cells and skin samples.

Implementation Method 1

stimulating adipogenesis and lipogenesis to reduce signs of skin aging

Methodology Applied

Scientific EffectAdipogenesis:

Implementation Method 2

stimulating adipogenesis and lipogenesis to reduce signs of skin aging

Methodology Applied

Scientific EffectLipogenesis:

Data Source

PatentUS10123964B2Topical composition including a combination of extracts for reducing signs of skin aging

Publication Date: 2018.11.13 KIMBERLY CLARK WORLDWIDE INC

AI summary

Compositions for reducing skin aging are disclosed herein. The compositions can be topically applied to a skin region to reduce or prevent skin wrinkles, fine lines, thinning skin, sagging skin, skin dryness, and skin itchiness.