Topical Composition for Skin Restoration via Biochemical Substitution

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Solution Overview

Problem

Aging skin loses firmness and elasticity due to diminished glycosaminoglycans and proteoglycans in the dermis, leading to wrinkles and sagging, which current remedies such as plastic surgery and botulinum toxin injections do not adequately address.

Innovation Solution

A topical composition comprising N-acetyl-glucosamine-6-phosphate, glucuronic acid, and magnesium sulfate in specific proportions, which promotes the restructuring of dermal components like collagen and elastin, and regeneration of glycosaminoglycans and proteoglycans, improving skin mechanical properties and reducing sagging and wrinkling.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If plastic surgery or botulinum toxin injections are used to address skin aging, then visible wrinkles and sagging are reduced, but the treatment is invasive, expensive, and does not address the underlying biochemical deficiency

Engineering Contradiction:

Improveeffectiveness of skin restorationVSAvoidinvasiveness of treatment

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent replaces mechanical/invasive interventions (surgery, injections) with a biochemical solution - a topical composition containing specific glycosaminoglycans and proteoglycans that directly address the underlying biochemical deficiency in aged skin, restoring extracellular matrix components without physical intrusion into tissue

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces intermediary biochemical substances (glycosaminoglycans like chondroitin sulfate, dermatan sulfate, heparan sulfate, and proteoglycans) that mediate between the applied topical composition and the skin's extracellular matrix, facilitating regeneration and restructuring of dermal components

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If conventional skin treatments are used, then some cosmetic improvement is achieved, but they fail to regenerate the diminished glycosaminoglycans and proteoglycans in the dermis

Engineering Contradiction:

Improvecosmetic improvementVSAvoidregeneration of glycosaminoglycans and proteoglycans

Core Design Contradiction:

ReliabilityVSLoss of substance

Solution Approach 1:

The patent applies glycosaminoglycans and proteoglycans topically before significant dermal degradation occurs, or at the onset of aging signs, to prevent further loss and stimulate regeneration of these essential extracellular matrix components, addressing the biochemical deficiency before it becomes severe

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent changes the biochemical composition parameters of the skin by introducing specific concentrations of glycosaminoglycans (chondroitin sulfate, dermatan sulfate, heparan sulfate) and proteoglycans, altering the extracellular matrix composition to restore youthful skin properties and counteract aging-related diminishment

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS11026875B2Skin restoration product

Publication Date: 2021.06.08 GIVAUDAN SA

AI summary

A composition comprising N-acetyl-glucosamine-6-phosphate, glucuronic acid, and a magnesium sulfate in the proportions of 50 to 75, 55 to 83 and 33 to 66 mmoles/kg respectively. The composition has restorative effects on aged and wrinkled skin.