Topical Formulation Using Purified Omega-3 and Melatonin
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Solution Overview
Problem
Current topical formulations face challenges in effectively rebalancing dysbiosis, strengthening skin and mucosal barriers, and reducing chronic inflammation, while also being well-tolerated and accepted by users, due to issues such as instability, odor, and residual effects.
Innovation Solution
Topical formulations comprising omega-3 fatty acids, melatonin, vitamin D3, and optionally β-glucan, formulated to be rheologically stable, quickly absorbed, and odor-free, which synergistically affect the microbiome and immune response, serving as both therapeutic agents and carriers for other pharmaceuticals.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If fish oil is used as a source of omega-3 fatty acids in topical formulations, then the therapeutic effectiveness is improved, but the formulation develops unpleasant odor and poor stability due to oxidation
Solution Approach 1:
The patent extracts and isolates specific omega-3 fatty acids (EPA and DHA) from fish oil in purified form. By separating the therapeutic active ingredients from the problematic fish oil matrix, the formulation achieves both therapeutic effectiveness and stability without oxidation or unpleasant odor.
Solution Approach 2:
The patent changes the chemical state of omega-3 fatty acids from their natural fish oil triglyceride form to purified free fatty acid or ester forms. This parameter change in molecular structure and purity eliminates the oxidation-prone characteristics of fish oil while preserving the therapeutic benefits of EPA and DHA.
2Strength
If conventional topical formulations are applied to strengthen skin and mucosal barriers, then barrier function is improved, but the formulations cause allergic reactions, rashes, and exacerbation of initial problems
Solution Approach 1:
The patent creates a biologically inert and compatible environment by using purified omega-3 fatty acids, melatonin, and vitamin D3 - all substances that are naturally present in the body and unlikely to cause allergic reactions. This inert formulation approach strengthens barriers without triggering immune responses or irritation.
Solution Approach 2:
The formulation uses substances that work with the body's natural physiological processes rather than against them. Omega-3 fatty acids incorporate into cell membranes, melatonin regulates circadian rhythms in skin cells, and vitamin D3 modulates immune function - all supporting the body's own barrier strengthening mechanisms without causing adverse reactions.
3Object-affected harmful factors
If existing medications are used to reduce chronic inflammation, then inflammation is reduced, but the medications fail to address the underlying dysbiosis and barrier dysfunction
Solution Approach 1:
The patent creates a multi-functional formulation where omega-3 fatty acids address barrier dysfunction and dysbiosis, melatonin addresses inflammation and barrier strengthening, and vitamin D3 addresses both immune modulation and barrier function. This single formulation simultaneously targets multiple aspects of the disease process rather than treating only inflammation.
Solution Approach 2:
The formulation takes preliminary action by addressing the root causes of inflammation - dysbiosis and barrier dysfunction - before inflammation fully develops. By restoring barrier integrity and balancing microbiota first, the formulation prevents the cascade that leads to chronic inflammation rather than merely treating the inflammatory symptoms.
Data Source
AI summary
The present disclosure provides topical formulations comprising omega-3 fatty acids, melatonin, vitamin D3 and optionally β-glucan. The formulations are designed for application to either the skin or mucosa of a subject in need thereof. The present disclosure also provides methods of treatment or prevention of a variety of conditions by applying the formulations to the skin or mucosa of the subject, including various skin conditions, eye disorders and sleep disorders.