Topical Gel Composition with Non-Carbomer Rheology Modifier

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Solution Overview

Problem

Current topical pharmaceutical compositions often cause irritation and are not storage stable, making them ineffective for conditions like moccasin-type Tinea pedis, which typically requires oral antifungal medication for treatment.

Innovation Solution

A gel composition comprising a solvent, non-carbomer rheology modifier, active agent, and optional solubilizing agents, preservatives, and pH adjusters, formulated to reduce irritation and improve delivery of the active agent, achieving a viscosity of 55,000 to 70,000 centipoise for effective topical treatment.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional topical pharmaceutical compositions are used, then active agent delivery is achieved, but irritation and lack of storage stability occur

Engineering Contradiction:

Improvestorage stabilityVSAvoidirritation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the rheological parameters of the gel composition by using non-carbomer rheology modifiers to achieve a viscosity of 55,000 to 70,000 centipoise. This parameter change improves storage stability while maintaining reduced irritation compared to conventional formulations

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite gel composition combining specific rheology modifiers, solvents, and active agents. This composite formulation achieves both storage stability and reduced irritation by integrating multiple components that work synergistically

Inventive Principle:

Principle #40Composite materials

2Productivity

If conventional topical compositions are used, then treatment is provided, but frequent dosing is required and delivery is insufficient

Engineering Contradiction:

Improvedelivery efficiencyVSAvoiddosing frequency

Core Design Contradiction:

ProductivityVSLoss of time

Solution Approach 1:

The patent optimizes the viscosity parameter to 55,000-70,000 centipoise, which enhances the delivery efficiency of the active agent. This improved delivery allows for less frequent dosing while maintaining effective treatment levels

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The gel composition provides continuous delivery of the active agent through its rheological properties, maintaining therapeutic levels over extended periods. This continuous action reduces the need for frequent dosing and improves treatment efficacy

Inventive Principle:

Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The gel composition provides improved delivery of the active agent with reduced irritation and enhanced storage stability, allowing for less frequent dosing and effective treatment of conditions like moccasin-type Tinea pedis without the need for oral medication.

Implementation Method 1

a non-carbomer rheology modifier... achieving a viscosity of 55,000 to 70,000 centipoise

Methodology Applied

Scientific EffectRheology modification:

Data Source

PatentUS10695303B2Topical compositions and methods for making and using same

Publication Date: 2020.06.30 LEGACY PHARMA INC

AI summary

The present invention relates to improved topical gel compositions comprising an active agent, and uses thereof.