Topical Sanitizing Composition That Boosts AMPs Without Skin Irritation

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Solution Overview

Problem

Existing skin disinfecting or sanitizing compositions often cause skin irritation while attempting to increase the concentration of antimicrobial peptides (AMPs) for enhanced germ defense.

Innovation Solution

A topical composition containing 0.02 wt.% to 10.0 wt.% of an active ingredient, such as natural extracts or polypeptides, along with 40 wt.% to 95 wt.% C1-6 alcohols, and optional humectants, moisturizing esters, and emollients, which increases AMP concentration without causing skin irritation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If high concentration of antimicrobial peptides is used to enhance germ defense, then antimicrobial effectiveness is improved, but skin irritation increases

Engineering Contradiction:

Improveantimicrobial effectivenessVSAvoidskin irritation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent introduces probiotic bacteria (Lactobacillus rhamnosus GG) as an intermediary organism that naturally produces antimicrobial peptides. Instead of directly applying high concentrations of AMPs which cause irritation, the composition uses probiotics as living factories that generate AMPs in situ, thereby achieving effective germ defense while avoiding the harmful effects of direct AMP application.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The probiotic bacteria in the composition serve themselves by naturally producing antimicrobial peptides as part of their metabolic function. The Lactobacillus rhamnosus GG strain autonomously generates AMPs to protect the skin, eliminating the need for external supplementation of AMPs and avoiding the irritation associated with high concentrations of added peptides.

Inventive Principle:

Principle #25Self-service

2Reliability

If alcohol-based sanitizing compositions are used to kill microorganisms, then germ control is improved, but skin irritation increases

Engineering Contradiction:

Improvegerm controlVSAvoidskin irritation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent fundamentally changes the active ingredient parameter from alcohol to probiotic bacteria. This parameter change transforms the mechanism of action from direct chemical killing (alcohol) to biological defense (probiotics producing AMPs), thereby maintaining effective germ control while eliminating the skin irritation caused by alcohol-based formulations.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent converts the potential harm of using strong antimicrobial agents into benefit by using gentle probiotic bacteria that naturally produce antimicrobial peptides. The probiotics provide the beneficial germ-killing effect while their biological nature avoids the harmful irritation associated with chemical antimicrobials like alcohol.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Data Source

PatentUS12539324B2Antimicrobial peptide stimulating sanitizing composition

Publication Date: 2026.02.03 GOJO IND INC

AI summary

A method of increasing antimicrobial peptide concentration on the skin is provided. The method includes cleaning skin with at least one of a cleanser and a sanitizer and applying a topical composition to the skin. The topical composition is comprised of one or more polypeptides and natural extracts that increase the concentration of antimicrobial peptides.