Topical Solvent Composition for Erectile Dysfunction Without GTN

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Solution Overview

Problem

Existing treatments for erectile dysfunction, such as those containing glyceryl trinitrate (GTN), suffer from side effects like headaches and are contraindicated for users taking nitrate-containing medications, and there is a desire for formulations without synthetic chemicals.

Innovation Solution

A composition comprising volatile and non-volatile solvents, including lower alcohols and polyhydric alcohols and glycols, without GTN, sildenafil, or acetylcholinesterase inhibitors, that enhances endogenous nitric oxide production through physical stimulation, promoting tumescence and erection.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If GTN-containing compositions are used to treat erectile dysfunction, then efficacy is improved, but side effects (headaches) and contraindications increase

Engineering Contradiction:

ImproveefficacyVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent removes GTN (glyceryl trinitrate) from the composition entirely, extracting the harmful nitrate component while retaining the solvent system. The composition now contains only volatile solvents (lower alcohols like ethanol/propanol and water) and non-volatile solvents (polyhydric alcohols like glycerol and glycols like propylene glycol), eliminating headaches and contraindications associated with nitrate-containing medications.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The composition enables the body's own physiological systems to work naturally by providing a safe environment for endogenous nitric oxide production. Instead of introducing exogenous nitrates that cause side effects, the formulation allows the penile tissue to naturally produce nitric oxide in response to stimulation, with the solvent blend optimizing this natural process.

Inventive Principle:

Principle #25Self-service

2Reliability

If GTN-containing compositions are used, then treatment effectiveness is improved, but adaptability to users taking nitrate medications deteriorates

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidadaptability to nitrate medication users

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent extracts the nitrate component (GTN) from the formulation, making the composition compatible with users taking nitrate-containing medications for conditions like angina. The solvent-only formulation (lower alcohols, water, polyhydric alcohols, and glycols) eliminates the drug interaction risk while maintaining effectiveness through enhanced endogenous nitric oxide production.

Inventive Principle:

Principle #2Taking out (Extraction)

3Reliability

If synthetic chemicals like GTN are used, then pharmacological efficacy is improved, but naturalness and safety profile deteriorate

Engineering Contradiction:

Improvepharmacological efficacyVSAvoidsynthetic chemical concerns

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent uses volatile solvents (lower alcohols and water) that evaporate completely after application, leaving no residual synthetic chemicals. The volatile nature of ethanol, propanol, and water ensures the composition breaks down into harmless components, aligning with natural processes and eliminating concerns about persistent synthetic chemicals in the body.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively treats erectile dysfunction without GTN, reducing side effects and contraindications, while maintaining efficacy comparable to GTN-containing formulations.

Implementation Method 1

the composition is to provide rapid initial absorption of GTN and an ongoing slow absorption as the volatile solvents evaporate in use so that the GTN concentration is dynamically maintained

Methodology Applied

Scientific EffectEvaporation: Evaporation

Implementation Method 2

enhances endogenous nitric oxide production through physical stimulation, promoting tumescence and erection

Methodology Applied

Scientific EffectNitric oxide production:

Data Source

PatentUS12576152B2Topical composition

Publication Date: 2026.03.17 FUTURA MEDICAL DEV LTD

AI summary

There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.