Topical Vitamin D and Ubiquinol Emulsion for Oral Inflammation

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Solution Overview

Problem

Current treatments for oral inflammation and oxidative stress, such as periodontitis, are inadequate in maintaining adequate vitamin D and UBIQUINOL levels, leading to persistent inflammation and potential progression to more severe conditions like periodontitis, and existing methods face challenges in achieving sustained release and effective absorption of these supplements.

Innovation Solution

A topical, aqueous-free emulsion composition containing vitamin D and UBIQUINOL, stabilized with ascorbyl palmitate, propylene glycol, and carboxymethylcellulose, combined with trans-oral mucosal absorption facilitators and spilanthes extract, forms a mucoadhesive gel that gradually releases the supplements, allowing passive diffusion through the oral mucosa, thereby maintaining adequate vitamin D and UBIQUINOL levels and regulating immune response.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If topical vitamin D and ubiquinol supplements are applied to treat oral inflammation, then antimicrobial peptide production increases and oxidative stress reduces, but maintaining adequate supplement levels in the oral cavity is challenging due to poor absorption and lack of sustained release

Engineering Contradiction:

Improvetherapeutic effect consistencyVSAvoidsupplement concentration in oral cavity

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The composition is prepared in advance with mucoadhesive properties and encapsulated in a dissolvable matrix, allowing it to be applied topically and immediately adhere to the oral mucosa before gradual dissolution releases the supplements sustainably

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

Mucoadhesive polymers and encapsulating materials serve as intermediaries between the supplement and oral cavity environment, facilitating controlled release and maintaining supplement concentration at the application site

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If high doses of vitamin D are administered to ensure adequate levels, then immune response regulation improves, but the risk of hypercalcemia increases

Engineering Contradiction:

Improveimmune response regulationVSAvoidhypercalcemia risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The composition delivers vitamin D locally to the oral cavity through mucoadhesive topical application, creating a localized high concentration at the site of inflammation while avoiding systemic high doses that would cause hypercalcemia

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The formulation changes the delivery parameter from systemic oral ingestion to localized topical application, enabling controlled local concentration that achieves therapeutic effect without systemic toxicity

Inventive Principle:

Principle #35Parameter changes

3Quantity of substance

If oral supplements are used to maintain vitamin D and ubiquinol levels, then systemic availability improves, but absorption efficiency is poor and sustained release is difficult to achieve

Engineering Contradiction:

Improvesystemic supplement availabilityVSAvoidabsorption efficiency

Core Design Contradiction:

Quantity of substanceVSEase of manufacture

Solution Approach 1:

The invention replaces the gastrointestinal absorption mechanism with direct mucosal absorption through topical application, bypassing the inefficient digestive system and enabling direct entry into circulation through the highly permeable oral mucosa

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively treats oral inflammation by increasing antimicrobial peptide production and reducing oxidative stress, providing sustained therapeutic effects by maintaining adequate vitamin D and UBIQUINOL levels, minimizing the risk of hypercalcemia, and promoting a controlled immune response.

Implementation Method 1

forms a saliva soluble, mucoadhesive gel, substantive to said oral mucosa

Methodology Applied

Scientific EffectMucoadhesion: Adhesive

Implementation Method 2

said vitamin D and UBIQUINOL supplement mixture, trans-oral mucosal, absorption facilitator and spilanthes extract passively diffuse through said oral mucosa

Methodology Applied

Scientific EffectPassive diffusion: Diffusion

Implementation Method 3

Stable UBIQUINOL supplements for the purposes of the present invention are represented by the following structural formula... Suitable UBIQUINOL supplements for the purposes of this invention include a stabilizing composition comprising ascorbyl palmitate

Methodology Applied

Scientific EffectAntioxidation: Oxidation

Data Source

PatentUS9877929B2Topical vitamin D and ubiquinol oral supplement compositions

Publication Date: 2018.01.30 PREMIER DENTAL PRODUCTS CO LLC

AI summary

A topical vitamin D and UBIQUINOL supplement composition useful in treating oral inflammation and reducing oxidative stress comprising: a supplement mixture of vitamin D and UBIQUINOL in an aqueous-free emulsion containing: spilanthes extract, stabilizing compositions for UBIQUINOL and trans-oral mucosal absorption facilitators for the supplement mixture; where the emulsion forms a mucoadhesive gel in the presence of saliva, that effects passive diffusion through the oral mucosa of the supplement mixture and spilanthes extract regulating: in vivo availability and immune response of the supplement mixture, and maintaining adequate levels of circulating vitamin D and of adjunctively administered UBIQUINOL, while minimizing the risk of hypercalcemia.