Topramezone Derivative Composition for Rainfast Corn Weed Control
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Solution Overview
Problem
Existing herbicides like Topramezone have issues with herbicide-resistant weeds, poor rainfastness, and high application costs, leading to challenges in controlling weeds in corn fields, particularly affecting sedge and broadleaf weeds.
Innovation Solution
Development of Topramezone derivatives, specifically Compounds I and II, which exhibit improved rainfastness and enhanced efficacy against sedge and broadleaf weeds, including formulations such as wettable powder, water dispersible granule, and suspension concentrate.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Topramezone is used to control weeds in corn fields, then herbicidal efficacy is achieved, but rainfastness is poor leading to washed away by rainfall
Solution Approach 1:
The patent modifies the chemical structure of Topramezone by changing parameters at specific positions (R1, R2, R3, R4, R5, R6 substituents) to create derivatives with improved rainfastness while maintaining herbicidal efficacy. This involves altering molecular weight, polarity, and hydrophobicity parameters to reduce washoff by rainfall.
Solution Approach 2:
The patent creates composite herbicide formulations combining Topramezone derivatives with adjuvants such as surfactants, oils, or polymers that enhance rainfastness. These composite formulations improve retention on plant surfaces and reduce washoff while maintaining the original herbicidal activity.
2Ease of manufacture
If Topramezone is used alone, then application cost is reduced, but control efficacy on sedge and broadleaf weeds is poor
Solution Approach 1:
The patent merges Topramezone derivatives with other herbicides having different modes of action and target weed spectra. This combination approach achieves synergistic or additive effects, improving control efficacy on sedge and broadleaf weeds while potentially reducing the required dosage and overall application cost compared to using multiple herbicides separately.
Solution Approach 2:
The patent develops Topramezone derivatives with broadened spectrum of activity that can control multiple types of weeds (grassy, sedge, and broadleaf) with a single application. This multi-functional derivative replaces the need for multiple specialized herbicides, reducing application costs while maintaining or improving control efficacy.
3Reliability
If Topramezone is used, then broadleaf weed control is achieved, but continuous-control ability is poor
Solution Approach 1:
The patent employs Topramezone derivatives with modified pharmacokinetic properties that provide preliminary and sustained action against broadleaf weeds. The derivatives are designed to be absorbed and translocated more effectively, providing prolonged residual activity in the plant system that extends continuous control ability beyond the initial application effect.
Solution Approach 2:
The patent creates herbicide formulations with controlled-release properties that maintain continuous presence of the active ingredient at effective concentrations. This may involve encapsulation technologies, slow-release carriers, or formulations that progressively release the herbicide, ensuring continuous control action against broadleaf weeds over an extended period.
Data Source
AI summary
A Topramezone derivative or an agrochemically acceptable salt thereof is provided. The Topramezone derivative is Compound I, with a name of 1-((4-(3-(4,5-dihydroisoxazol-3-yl)-2-methyl-4-(methylsulfonyl)benzoyl)-1-methyl-1H-pyrazol-5-yl)oxy)ethyl methyl carbonate, and a structural formula of: