Toroidal Pharmaceutical Formulations for Ocular Delivery
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Solution Overview
Problem
Current methods for administering therapeutic agents to the eye, such as drops and aerosols, face challenges including inaccuracy, inefficiency, and discomfort due to mechanical delivery issues and rapid removal of the agent, leading to variable dosing and reduced effectiveness.
Innovation Solution
A toroidal aerosol delivery system that dispenses a toroidal pharmaceutical composition, which is a doughnut-shaped aerosolized therapeutic agent, allowing for precise control over the size, shape, and velocity of the aerosol to ensure targeted and controlled delivery to the eye, optimizing deposition and retention.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If drops are used to administer therapeutic agents to the eye, then a large quantity of liquid can be delivered, but this results in therapeutic agent loss, uncontrolled dose, rapid removal of drops, and uncomfortable administration
Solution Approach 1:
The invention changes the physical parameters of the administered substance from liquid drops to aerosolized microparticles. This transformation allows the therapeutic agent to be delivered in a controlled aerosol form that remains suspended in the air longer, enabling precise dosing without the rapid removal and loss associated with liquid drops. The aerosolized particles can be inhaled and retained in the respiratory tract more effectively.
2Quantity of substance
If drops are used to administer therapeutic agents to the eye, then a large quantity of liquid can be delivered, but this results in uncontrolled dose and rapid removal of drops
Solution Approach 1:
The invention replaces the mechanical instillation process of liquid drops with an aerosolization system that uses ultrasonic vibration or other mechanisms to generate controlled microparticles. This substitution enables precise control over particle size, concentration, and delivery rate, achieving accurate dosing that cannot be obtained with manual drop administration.
3Ease of operation
If aerosol plume is used to deliver therapeutic agents, then delivery can be achieved, but the aerosol plume geometry is difficult to control and the force of the aerosol plume is uncomfortable
Solution Approach 1:
The invention segments the aerosol delivery into controlled microparticle sizes (1-10 micrometers) that can be independently optimized for different therapeutic purposes. By controlling the size distribution and spatial distribution of particles, the system achieves precise geometry control while maintaining comfortable delivery forces through optimized particle velocity and concentration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The toroidal aerosol delivery system provides a controlled and efficient method for administering therapeutic agents to the eye, ensuring higher deposition and retention of the active pharmaceutical ingredient, reducing waste and improving patient comfort.
Implementation Method 1
an aerosol generator in fluid communication with the aerosol chamber, the aerosol generator adapted to charge the aerosol chamber with an aerosolized therapeutic agent
Implementation Method 2
allowing the toroidal pharmaceutical composition to contact a target organ of the subject, thereby administering the toroidal pharmaceutical composition
Data Source
AI summary
There is provided methods for administering a toroidal pharmaceutical composition to a subject. The method includes dispensing a toroidal pharmaceutical composition, and allowing the toroidal pharmaceutical composition to contact a target organ of the subject, thereby administering the toroidal pharmaceutical composition. There are additionally provided toroidal aerosol delivery systems.