Toroidal OAM Field Perturbation for Neuronal Stimulation
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Solution Overview
Problem
Perturbation of cells and/or cellular components such as neurons in living subjects remains a challenge due to the need for sufficient sensitivity, targeted perturbation, and minimization of tissue damage.
Innovation Solution
The use of plural non-zero orbital angular momentum (OAM) quantum particles, such as photons, to achieve perturbation by generating a toroidal intensity distribution field that is delocalized in space, allowing for effective membrane depolarization and activation of neurons while minimizing tissue damage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional photostimulation methods are used to achieve sufficient sensitivity for neuronal perturbation, then perturbation effectiveness is improved, but tissue damage increases
Solution Approach 1:
The patent applies local quality by creating a toroidal intensity distribution with a dark center region that selectively concentrates photostimulation at the neuronal membrane while sparing the nuclear region. This spatial differentiation of intensity quality enables effective membrane depolarization without damaging the vulnerable nuclear area, thus achieving reliable perturbation without excessive tissue damage
Solution Approach 2:
The patent uses non-zero OAM quantum particles as an intermediary to achieve perturbation. These quantum particles with orbital angular momentum serve as a mediator that can deposit energy selectively at the membrane through quantum tunneling and angular momentum transfer, avoiding direct high-intensity focal illumination that would cause tissue damage while still achieving sufficient perturbation effectiveness
2Manufacturing precision
If focused illumination is used to achieve targeted perturbation at specific neuronal locations, then perturbation precision is improved, but spurious focal regions outside target plane increase
Solution Approach 1:
The patent transitions from conventional planar focusing to three-dimensional toroidal intensity distribution by utilizing the orbital angular momentum dimension of quantum particles. This dimensional transformation creates a donut-shaped intensity pattern with a dark core that extends along the optical axis, enabling precise targeting at the intended plane while inherently suppressing spurious focal regions at other depths through the extended toroidal geometry
Solution Approach 2:
The patent applies local quality by creating a toroidal intensity distribution with a dark center region that selectively concentrates photostimulation at the neuronal membrane while sparing the nuclear region. This spatial differentiation of intensity quality enables effective membrane depolarization without damaging the vulnerable nuclear area, thus achieving reliable perturbation without excessive tissue damage
3Reliability
If high intensity illumination is used to achieve perturbation at tissue depths of 2-3 mm, then perturbation capability is improved, but tissue damage increases
Solution Approach 1:
The patent changes the fundamental parameters of the illumination by using non-zero OAM quantum particles with orbital angular momentum instead of conventional photons. This parameter change results in a toroidal intensity distribution with extended spatial localization that maintains sufficient intensity at tissue depths of 2-3 mm while distributing the energy load to avoid localized tissue damage, achieving deep tissue perturbation capability without proportional increase in damage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach provides sufficient sensitivity for perturbation while minimizing damage outside the targeted plane and avoiding tissue damage, even at tissue depths of up to 2 or 3 mm.
Implementation Method 1
utilizes multiple quantum particles, e.g., photons, with non-zero OAM. Non-zero OAM quantum particles are in a distinct topological quantum state that is spatially extended in its localization probability, thus generating a toroidal intensity distribution field (waveform)
Implementation Method 2
an focus or objective (or other suitable component) configured to condense the vortex to a target plane within a depth of tissue
Data Source
AI summary
Systems and methods of the present disclosure include plural non-zero Orbital Angular Momentum (OAM) quantum particles utilized to generate a toroidal (and, in aspects super-twised) intensity of Electro-Magnetic (EM) field radiation that is delocalized in space and spans the whole toroid with zero or near-zero amplitude at its center are tuned (e.g., varied) in diameter to enable perturbation, e.g., stimulation, of a target at a target plane (or planes) with, for example, effective depolarization and activation of the target while inhibiting the establishment of spurious and damaging focal regions of the quantum particles' intensity.