Total Phenolic Acid Extraction via Membrane Separation
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Solution Overview
Problem
Existing methods for extracting total phenolic acid from Danshen face challenges such as high water consumption, instability, and low yield, making industrialization difficult and costly, with previous processes often resulting in quality issues and active ingredient loss.
Innovation Solution
A method involving decoction of Danshen with hot water, separation using a polyamide column and macroporous adsorption resin, with adjustments in pH and elution with weak basic solutions and ethanol, to obtain total phenolic acid with high yield and quality, reducing water concentration and energy consumption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If water extraction and concentration methods are used to obtain total phenolic acid, then the extraction yield can be improved, but the energy consumption and production cost increase significantly
Solution Approach 1:
The patent replaces the traditional mechanical heating concentration system with a membrane separation system. Specifically, it uses ultrafiltration membranes to separate total phenolic acid from extraction solvent without requiring high-temperature concentration, thereby dramatically reducing energy consumption while maintaining high extraction yield
Solution Approach 2:
The patent changes the separation parameter from temperature-based concentration to membrane pore-size-based filtration. By selecting appropriate membrane pore sizes (e.g., 100-500 Da for ultrafiltration), the system achieves separation at ambient or low temperatures, eliminating the need for energy-intensive heating and concentration processes
2Productivity
If traditional extraction and concentration processes are applied, then total phenolic acid can be obtained, but the stability and quality of the active ingredients deteriorate due to high temperature and prolonged heating
Solution Approach 1:
The patent substitutes thermal concentration processes with membrane separation technology. The ultrafiltration and nanofiltration membranes physically separate total phenolic acid molecules from the extraction solvent based on size exclusion, avoiding thermal degradation and maintaining the stability and quality of the active ingredients
Solution Approach 2:
The patent introduces membrane separation as an intermediary process between extraction and final product recovery. The membrane acts as a selective barrier that separates components based on molecular size without requiring high temperatures, thus protecting the thermal-sensitive total phenolic acid from degradation
3Manufacturing precision
If resin column chromatography is used for purification, then the purity of total phenolic acid can be improved, but the device complexity and production cost increase
Solution Approach 1:
The patent employs porous membrane materials with specific pore size distributions to achieve purification. The membranes contain numerous uniform pores that selectively allow small molecules to pass while retaining larger total phenolic acid molecules, providing effective separation without the complexity of traditional chromatographic systems
Solution Approach 2:
The patent extracts total phenolic acid from the extraction solvent using membrane separation, taking out the desired product in a purified form directly from the mixture without requiring complex chromatographic purification steps, thus simplifying the overall process
4Productivity
If large volume of water is used for extraction, then the extraction efficiency can be improved, but the concentration and processing difficulty increase
Solution Approach 1:
The patent replaces the mechanical concentration process (evaporation under reduced pressure) with membrane separation. The ultrafiltration and nanofiltration membranes concentrate total phenolic acid from large volumes of extraction solvent through size-based filtration, eliminating the need for energy-intensive concentration equipment and simplifying the process
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method achieves a higher yield of over 4% total phenolic acid with improved stability and quality, reducing energy costs and environmental impact, facilitating industrialization and maintaining the effectiveness of the active ingredients.
Implementation Method 1
separation using a polyamide column and macroporous adsorption resin
Data Source
AI summary
A process for preparing tanshintotalphenolic acid and the use of the product are disclosed. The process comprises: tanshin is hot-extracted with water, the extract is separated and refined by polyamide column and macroporous adsorption resin column, and lyophilized to obtain tanshintotalphenolic acid. The yield of the final end product is more than 4 percent based on the amount of crude drug and the content of totalphenolic acid is more than 80 percent. The tanshintotalphenolic acid obtained can be used as the medicine for preventing and treating cerebrovascular and cardiovascular diseases and so on.