Trans Sodium Crocetinate Oxygen Diffusivity
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Solution Overview
Problem
Current methods for improving peripheral tissue oxygenation and treating conditions characterized by hypoxia, such as interstitial lung disease, are inadequate as they often lead to hyperoxygenation or do not effectively enhance oxygen delivery to tissues.
Innovation Solution
Administration of a therapeutically effective amount of a diffusion enhancing compound, specifically trans sodium crocetinate (TSC), which increases oxygen diffusivity without causing hyperoxygenation, formulated with cyclodextrin for enhanced solubility and bioavailability, administered intravenously or intramuscularly.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional methods are used to improve peripheral tissue oxygenation, then oxygen delivery is enhanced, but hyperoxygenation occurs causing adverse effects
Solution Approach 1:
The patent changes the physical-chemical parameter of oxygen by introducing a diffusion-enhancing compound that increases oxygen diffusivity rather than oxygen concentration. This allows oxygen to be delivered more efficiently to tissues through enhanced diffusion rates, avoiding the hyperoxygenation that occurs with conventional oxygen supplementation methods
Solution Approach 2:
The diffusion-enhancing compound acts as an intermediary substance that facilitates oxygen transport from the blood to tissues. Rather than directly increasing oxygen concentration (which causes hyperoxygenation), this intermediary compound enhances the diffusion process itself, enabling improved oxygen delivery without adverse effects
2Quantity of substance
If oxygen concentration is increased to treat hypoxia, then tissue oxygenation improves, but toxicity and adverse effects occur
Solution Approach 1:
Instead of changing the concentration parameter of oxygen (which leads to toxicity), the patent changes the diffusion parameter by introducing a compound that enhances oxygen diffusivity. This allows adequate tissue oxygenation to be achieved through improved diffusion kinetics rather than increased oxygen concentration, avoiding oxygen toxicity
3Speed
If diffusion enhancing compound is administered, then oxygen diffusivity increases, but solubility and bioavailability are limited
Solution Approach 1:
The patent uses a composite approach by formulating the diffusion-enhancing compound with cyclodextrin, creating a composite material system. The cyclodextrin component enhances the solubility and bioavailability of the diffusion-enhancing compound, while the compound itself maintains its oxygen diffusion-enhancing properties, thus resolving the contradiction between diffusivity and solubility
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Effectively enhances oxygen delivery to tissues, improving peripheral tissue oxygenation, increasing oxygen transfer from lungs to blood and tissues, and improving exercise performance without causing hyperoxygenation, as demonstrated by increased TcpO2 values and improved exercise recovery.
Implementation Method 1
Carotenoids such as crocetin and trans sodium crocetinate (TSC) are known to increase the diffusivity of oxygen in water
Implementation Method 2
formulated with cyclodextrin for enhanced solubility and bioavailability
Data Source
AI summary
Provided are novel methods of treatment of conditions such as peripheral tissue oxygenation, interstitial lung disease, dyspnea, ischemia from surgery, brain and pancreatic cancer with increased oxygen diffusivity comprising administering a diffusion enhancing compound, for example, trans sodium crocetinate.