Dual-Mode Transdermal Applicator for Broad-Molecule Delivery
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Solution Overview
Problem
Existing iontophoresis, electroporesis, and sonophoresis systems are typically configured for distinct classes of molecules, leading to inconvenience and potential health complications due to inadequate treatment when delivering a wide range of molecule types through the skin.
Innovation Solution
A dual treatment system combining iontophoresis, electroporesis, and sonophoresis with a smart applicator capsule and control circuitry to deliver a composition through the skin using a rollerball, electrodes, and ultrasound transducer configured to transmit ultrasound for sonophoresis; and a body, configured for reversible attachment of the applicator capsule thereto, and comprising a contact-less piston configured to expel the composition from the reservoir; wherein one or more apertures of the applicator capsule fluidly connect the interior of the applicator capsule to an exterior of the applicator capsule for delivery of the composition from the reservoir to the portion of skin.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If distinct iontophoresis, electroporesis, and sonophoresis systems are used for different molecule types, then each system can be optimized for its specific molecule class, but the device complexity increases and requires multiple separate treatments
Solution Approach 1:
The patent combines iontophoresis, electroporesis, and sonophoresis systems into a single integrated device that can deliver different molecule types through the skin using multiple transmission methods, thereby reducing the need for multiple separate systems while maintaining optimized functionality for each molecule class
Solution Approach 2:
The device is designed with multi-functional capabilities to handle different molecule types (hydrophilic, lipophilic, large, small) through multiple transmission modes (iontophoresis, electroporesis, sonophoresis), making a single device universal for various transdermal delivery needs
2Reliability
If multiple separate treatment systems are used for different molecule types, then each system can be specialized, but the treatment time and patient inconvenience increase
Solution Approach 1:
By merging multiple treatment modalities into one device, the system allows simultaneous or sequential application of iontophoresis, electroporesis, and sonophoresis treatments in a single session, eliminating the need for multiple separate treatments and reducing overall treatment time
Solution Approach 2:
The device employs periodic or sequential activation of different transmission modes (iontophoresis, electroporesis, sonophoresis) to deliver various molecule types effectively within a single treatment session, optimizing treatment efficiency while maintaining reliability for each molecule class
3Adaptability or versatility
If a single system uses multiple transmission methods, then versatility improves, but the control and precision of each method may be compromised
Solution Approach 1:
The system incorporates dynamic control capabilities that allow real-time adjustment of transmission parameters (current, voltage, ultrasound frequency) for each method based on the specific molecule type being delivered, maintaining precision while accommodating versatility
Solution Approach 2:
The device enables parameter changes for each transmission method (iontophoresis current, electroporesis voltage pulses, sonophoresis ultrasound frequency and intensity) to optimize delivery for different molecule types while maintaining precise control through programmable settings
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively delivers a wide range of molecule types through the skin by combining iontophoresis, electroporesis, and sonophoresis, enhancing transdermal delivery and adherence to treatment plans.
Implementation Method 1
a contact-less piston configured to expel the composition from the reservoir
Implementation Method 2
a plurality of electrodes configured for a transmission of an electrical current through the portion of skin of the subject
Implementation Method 3
an ultrasound transducer configured to transmit ultrasound for sonophoresis; the sonophoresis creates one or more microchannels in a dermal layer of the portion of skin
Implementation Method 4
the contact-less piston is responsive to an activation of an electromagnet and the at least one operation comprises activation of the electromagnet for movement of the contact-less piston
Data Source
AI summary
Systems and methods for application of a composition to the skin of a subject using electroporation, iontophoresis, and in at least some instances, sonophoresis to facilitate penetration of the skin by one or more compounds of the composition, such as one or more drugs. A system includes an applicator capsule that includes a rollerball configured for a rolling contact with the portion of skin of the subject and a plurality of electrodes and/or ultrasound transducers that are configured for a transmission of an electrical current and/or ultrasound through the portion of skin of the subject. A formula pod of the system is reversibly attachable to the body and is configured to hold and release the composition therefrom for delivery of the composition from the formula pod to the portion of skin.