Transdermal Buffering Patch for Inflammatory Pain and Bone Decalcification
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Solution Overview
Problem
Current anti-inflammatory therapies are inadequate in effectively managing chronic inflammation, which can lead to tissue damage and negative physiological consequences, and there is a need for improved therapeutics that can reduce inflammation and associated pain without adverse effects.
Innovation Solution
A transdermal formulation comprising a therapeutically-effective amount of a buffering agent, which can be used alone or in combination with nonsteroidal medicaments and corticosteroids, administered for extended periods to reduce blood or serum levels of C-Reactive Protein, thereby addressing inflammation and related symptoms such as pain and joint issues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current anti-inflammatory therapies are used to treat chronic inflammation, then inflammation-related pain and symptoms are reduced, but adverse effects and inadequate effectiveness occur
Solution Approach 1:
The patent changes the chemical parameters of anti-inflammatory therapy by using buffering agents (sodium bicarbonate, sodium carbonate) with specific pH properties to neutralize inflammatory acidity. This parameter change provides effective inflammation treatment while avoiding the adverse effects associated with conventional anti-inflammatory drugs.
Solution Approach 2:
The patent employs inexpensive buffering agents that can be safely administered without the severe long-term side effects of traditional anti-inflammatories. These agents provide effective treatment for acute inflammatory episodes without accumulating harmful effects, functioning as safe, short-term therapeutic solutions.
2Object-affected harmful factors
If transdermal formulation with buffering agent is administered, then inflammation and pain are reduced with minimal adverse effects, but extended administration period is required
Solution Approach 1:
The transdermal formulation provides continuous delivery of buffering agents through the skin over extended periods. This continuous action maintains therapeutic levels of pH modulation at the inflammatory site, ensuring sustained inflammation reduction and pain relief with minimal adverse effects throughout the treatment period.
Solution Approach 2:
The transdermal system acts as an intermediary delivery mechanism, allowing buffering agents to be administered through the skin rather than orally or via injection. This intermediary approach enables extended administration with reduced systemic absorption and minimal adverse effects while maintaining therapeutic effectiveness.
3Reliability
If transdermal formulation is used to deliver buffering agent, then inflammation and pain are effectively treated, but formulation complexity increases
Solution Approach 1:
The patent uses a transdermal formulation consisting of a flexible adhesive patch with thin film structure. This simple yet effective design delivers buffering agents through the skin using basic transdermal technology, achieving effective inflammation treatment without excessive formulation complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The transdermal formulation effectively reduces inflammation, pain, and joint symptoms, improves physical function, and stabilizes calcium levels, reducing the need for rescue medications and improving patient satisfaction with minimal adverse effects.
Implementation Method 1
administering to the subject a transdermal formulation comprising a therapeutically-effective amount of a buffering agent
Implementation Method 2
A transdermal formulation comprising a therapeutically-effective amount of a buffering agent
Data Source
AI summary
The present disclosure relates to transdermal formulations, compositions, and methods for treating or preventing inflammation or a symptom thereof, e.g., inflammatory pain.