Transdermal Cannabinoid Formulation Without Harsh Penetration Enhancers
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Solution Overview
Problem
Current transdermal delivery methods for cannabinoids often rely on harsh penetration enhancers like solvents and phospholipids, which can irritate the skin, and existing skin protecting/enhancing ingredients are not effectively delivered to the top of the skin without causing irritation or absorption.
Innovation Solution
Development of compositions that deliver cannabinoids transdermally in therapeutically effective amounts without phospholipids or harsh penetration enhancers, while simultaneously delivering skin protecting/enhancing ingredients topically, using a bimodal pharmaceutical carrier that includes cannabinoids, skin protecting agents, and antioxidants.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If solvent-based penetration enhancers (DMSO, alcohols, glycols) are used for transdermal delivery, then cannabinoid delivery effectiveness is improved, but skin irritation occurs
Solution Approach 1:
The patent removes harmful penetration enhancers (solvents like DMSO, alcohols, glycols) from the formulation entirely, replacing them with a solvent-free system that uses the cannabinoid compounds themselves and benign carriers to achieve transdermal delivery without skin irritation
Solution Approach 2:
The patent employs simple, benign, short-acting carriers such as fatty acids, esters, and terpenes that naturally degrade and are rapidly metabolized by the skin, replacing persistent solvent-based enhancers with transient, safe alternatives that provide sufficient delivery without long-term irritation
2Reliability
If phospholipids (lecithin) are used for transdermal delivery, then cannabinoid penetration is improved, but skin irritation and allergic reactions occur
Solution Approach 1:
The patent extracts and removes phospholipids (particularly lecithin) from the formulation, eliminating the source of skin irritation and allergic reactions while maintaining transdermal delivery effectiveness through alternative mechanisms using fatty acids and terpenes
Solution Approach 2:
The patent introduces intermediary substances such as fatty acids, esters, and terpenes that act as mild carriers and penetration facilitators, replacing phospholipids with substances that mediate cannabinoid delivery without triggering immune responses or skin irritation
3Reliability
If skin protecting/enhancing ingredients are delivered topically, then skin condition improvement is achieved, but these ingredients are not effectively retained on the skin surface
Solution Approach 1:
The patent creates a composite formulation where skin protecting ingredients (antioxidants, moisturizers, anti-inflammatory agents) are combined with cannabinoid compounds and fatty acid carriers in a single integrated system that delivers all components synergistically, ensuring both cannabinoids penetrate and protective ingredients remain on the skin surface
Solution Approach 2:
The patent merges transdermal delivery of cannabinoids with topical delivery of skin protecting ingredients into a single formulation application, combining multiple therapeutic functions (pain relief, inflammation reduction, skin protection, moisturization) in one product that simultaneously addresses both deep tissue and surface skin needs
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution allows for effective transdermal delivery of cannabinoids and topical delivery of skin protecting agents, addressing skin conditions and enhancing skin appearance without skin irritation, and providing therapeutic benefits for disorders such as auto-immune diseases, cancer, and osteoarthritic disorders.
Implementation Method 1
pharmaceutical carrier effective for simultaneous transdermal delivery of the at least one cannabinoid compound
Implementation Method 2
capable of delivering the at least one cannabinoid compound transdermally while delivering the at least one skin protecting/enhancing ingredient topically
Data Source
AI summary
The present invention concerns formulations that provide for the transdermal delivery of canabinoid(s) in therapeutically effective amounts without the need for phospholipids or harsh irritating penetration enhancers while simultaneously delivering skin protecting/enhancing ingredients topically to the top of the skin for preventing and treating skin conditions and/or enhancing the appearance of skin.