Transdermal Cannabinoid Delivery via Polymer Adduct Sustained Release
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Solution Overview
Problem
Current transdermal delivery systems for CBD and THC face challenges in providing sustained and controlled release, effective penetration through skin tissue, and maintaining desired weight ratios, leading to inconsistent therapeutic effects.
Innovation Solution
A transdermal delivery composition comprising a cannabinoid mixture of CBD and THC at specific weight ratios, combined with a hydrophilic polymer/hydrophobic polymer adduct, surfactants, and a penetrant component, formulated to provide a sustained release and enhanced penetration through the skin over 4 to 12 hours, utilizing a polymer adduct to bind and release cannabinoids effectively.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a composition releases all or almost all of its CBD and THC at once, then the CBD and THC are available for transdermal delivery, but they are wiped away or washed away before systematic absorption and must be frequently applied
Solution Approach 1:
The patent employs a polymer matrix system that continuously releases CBD and THC from the composition over an extended period. The polymer network maintains the cannabinoids in a controlled release state, preventing wash-off while ensuring sustained transdermal delivery. This continuous action eliminates the need for frequent reapplication and maintains therapeutic levels in the skin tissue throughout the duration of action.
2Duration of action of moving object
If a composition holds onto its CBD and THC, then sustained release is achieved, but the CBD and THC are not available for transdermal delivery
Solution Approach 1:
The patent utilizes a dynamic polymer matrix system that adjusts the release rate of CBD and THC based on skin tissue conditions. The polymer network can shift between states of retention and release, allowing the cannabinoids to be held when needed and released when the skin is ready for absorption. This dynamic behavior ensures both sustained duration and effective delivery efficiency.
3Device complexity
If pure CBD and THC are used, then the composition is simple, but it does not effectively penetrate skin tissue for systematic effect
Solution Approach 1:
The patent creates a composite system combining CBD, THC, and specific polymers to form a unified matrix. This composite structure provides both the simplicity of a single composition and the complexity needed for effective skin penetration. The polymer components facilitate transdermal delivery while maintaining the therapeutic properties of the cannabinoids, achieving reliable penetration without significantly increasing overall composition complexity.
4Manufacturing precision
If CBD and THC are mixed into a composition at a specific weight ratio, then the desired ratio is provided, but the release ratio and penetration ratio can alter the ultimate delivered ratio
Solution Approach 1:
The patent incorporates a feedback mechanism within the polymer matrix system that monitors and adjusts the release of CBD and THC. The polymer network responds to skin tissue conditions and modifies the release rate to maintain the desired CBD:THC ratio throughout the duration of action. This feedback control ensures that despite variations in release and penetration rates, the final delivered ratio remains consistent with the formulation, providing both manufacturing precision and delivery reliability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves a consistent and prolonged release of CBD and THC, enhancing their systemic delivery and therapeutic efficacy while using a lower amount of cannabinoids, thus reducing costs and improving skin penetration.
Implementation Method 1
a hydrophilic polymer/hydrophobic polymer adduct in an amount sufficient to hold the cannabinoid composition and provide a sustain release of the cannabinoid mixture
Implementation Method 2
provide a sustain release of the cannabinoid mixture after application to skin tissue over a time period
Implementation Method 3
a penetrant component in an amount sufficient to assist with a transdermal penetration of the cannabinoid mixture through skin tissue
Implementation Method 4
a surfactant component in an amount sufficient to stabilize the polymer adduct and release the cannabinoid mixture from the transdermal delivery composition
Data Source
AI summary
A transdermal delivery composition for the delivery to skin and the penetration of the skin includes: (a) a therapeutic effective amount of a cannabinoid mixture, wherein the cannabinoid mixture comprises cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) at a weight ratio of about 1:20 to about 20:1; (b) a hydrophilic polymer/hydrophobic polymer adduct in an amount sufficient to hold the cannabinoid composition and provide a sustain release of the cannabinoid mixture after application to skin tissue over a time period of at least 6 hours; (c) a penetrant component in an amount sufficient to assist with a transdermal penetration of the cannabinoid mixture through skin tissue once the composition has been applied to skin tissue; (d) a surfactant component in an amount sufficient to stabilize the polymer adduct and release the cannabinoid mixture from the transdermal delivery composition upon application to skin tissue; and (e) at least about 70 wt. % water. A method of application of a transdermal delivery composition to skin tissue includes applying the transdermal delivery composition to skin tissue and spreading the composition to form a film on the skin tissue. A method for formulating a transdermal delivery composition based on a desired penetration weight ratio of CBD to THC through skin tissue includes selecting a formulation weight ratio of CBD to THC for formulating the composition, wherein the weight ratio is determined by multiplying the desired penetration weight ratio of CBD to THC by a CBD/TCH delivery factor, wherein the CBD/THC delivery factor.