Transdermal Cannabinoid Composition for Sustained Skin Penetration
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Solution Overview
Problem
Existing transdermal delivery systems for cannabidiol (CBD) and tetrahydrocannabinol (THC) face challenges in providing sustained and controlled release, effective penetration through skin, and maintaining desired weight ratios, leading to inconsistent therapeutic effects.
Innovation Solution
A transdermal delivery composition comprising a cannabinoid mixture of CBD and THC at specific weight ratios, a hydrophilic/hydrophobic polymer adduct for sustained release, a penetrant for enhanced skin penetration, and surfactants for stabilization, along with a water-based formulation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a composition releases all or almost all of its CBD and THC at once, then the CBD and THC are available for transdermal delivery, but they are wiped away or washed away before systematic absorption and must be frequently applied
Solution Approach 1:
The composition is pre-formulated with CBD and THC incorporated into the polymer matrix before application to skin. This preliminary incorporation ensures the cannabinoids are held in place during the delivery process, preventing them from being wiped or washed away while maintaining their availability for transdermal absorption over an extended period.
Solution Approach 2:
The invention uses a composite material system consisting of a polymer matrix (comprising polyvinylpyrrolidone and other polymers) combined with CBD and THC. This composite structure allows the cannabinoids to be sustained and controlled over time, resolving the contradiction between immediate availability and prolonged duration of action.
2Duration of action of moving object
If a composition holds onto its CBD and THC, then sustained release is achieved, but the CBD and THC are not available for transdermal delivery
Solution Approach 1:
The polymer matrix is designed with dynamic properties that allow it to progressively release CBD and THC over time. The matrix structure evolves from an initial state of holding the cannabinoids to a final state of sustained release, enabling both prolonged duration and continuous delivery efficiency through controlled degradation and diffusion processes.
Solution Approach 2:
The composition utilizes parameter changes in the polymer matrix, such as shifts in hydrophilicity and molecular weight, to control the release kinetics of CBD and THC. These parameter changes enable the matrix to transition from a state that holds the cannabinoids to one that facilitates their sustained transdermal delivery over extended periods.
3Device complexity
If pure CBD and THC are used, then the composition is simple, but it does not effectively penetrate skin tissue for systematic effect
Solution Approach 1:
The polymer matrix serves as an intermediary carrier that facilitates the penetration of CBD and THC through the skin. This intermediate structure enhances the reliability of transdermal delivery by improving the bioavailability and penetration efficiency of the cannabinoids, while the overall composition remains relatively simple and straightforward.
4Manufacturing precision
If CBD and THC are mixed into a composition at a specific weight ratio, then the desired therapeutic ratio is achieved, but the release ratio and penetration ratio can alter the ultimate ratio delivered
Solution Approach 1:
The composition formulation incorporates feedback mechanisms through the polymer matrix design, which compensates for potential variations in release and penetration ratios. This feedback approach ensures that even if the release or penetration ratios vary, the ultimate delivered ratio of CBD to THC remains consistent and reliable, maintaining manufacturing precision in the final therapeutic effect.
Data Source
AI summary
A transdermal delivery composition for the delivery to skin and the penetration of the skin includes: (a) a therapeutic effective amount of a cannabinoid mixture, wherein the cannabinoid mixture comprises cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) at a weight ratio of about 1:20 to about 20:1; (b) a hydrophilic polymer/hydrophobic polymer adduct in an amount sufficient to hold the cannabinoid composition and provide a sustain release of the cannabinoid mixture after application to skin tissue over a time period of at least 6 hours; (c) a penetrant component in an amount sufficient to assist with a transdermal penetration of the cannabinoid mixture through skin tissue once the composition has been applied to skin tissue; (d) a surfactant component in an amount sufficient to stabilize the polymer adduct and release the cannabinoid mixture from the transdermal delivery composition upon application to skin tissue; and (e) at least about 70 wt. % water. A method of application of a transdermal delivery composition to skin tissue includes applying the transdermal delivery composition to skin tissue and spreading the composition to form a film on the skin tissue. A method for formulating a transdermal delivery composition based on a desired penetration weight ratio of CBD to THC through skin tissue includes selecting a formulation weight ratio of CBD to THC for formulating the composition, wherein the weight ratio is determined by multiplying the desired penetration weight ratio of CBD to THC by a CBD/THC delivery factor, wherein the CBD/THC delivery factor.