Transdermal Drug Delivery Control Using Coupled Pressure and Temperature
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Solution Overview
Problem
Existing drug delivery devices suffer from low efficiency due to difficulties in drug absorption and administration, particularly in non-invasive skin penetration methods.
Innovation Solution
A drug delivery control method and apparatus that utilizes temperature and pressure coupling to control drug administration through non-invasive skin penetration, employing pressure and temperature parameters to create a pressure difference for efficient drug delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional drug administration modes (oral, injection, plaster, steam therapy) are used, then the drug can be administered, but the drug delivery efficiency is low and the drug absorption is insufficient
Solution Approach 1:
The patent changes physical parameters (temperature and pressure) to enhance drug penetration through the skin. By controlling temperature within 30-45℃ and pressure within 0.01-0.5MPa, the drug delivery efficiency is significantly improved compared to traditional administration modes, while maintaining reliable absorption effects.
Solution Approach 2:
The patent employs pressure control (0.01-0.5MPa) to create a pressure difference that facilitates drug penetration through the skin barrier. This hydraulic approach enables efficient non-invasive drug delivery while ensuring adequate absorption, resolving the contradiction between delivery efficiency and absorption reliability.
2Productivity
If temperature and pressure coupling control is applied for non-invasive skin penetration, then the drug delivery efficiency is improved, but the device complexity increases
Solution Approach 1:
The patent implements dynamic control of temperature (30-45℃) and pressure (0.01-0.5MPa) parameters during the drug delivery process. The system adjusts these parameters in real-time based on feedback, enabling efficient non-invasive penetration while managing complexity through adaptive rather than static control.
Solution Approach 2:
The patent incorporates feedback mechanisms to monitor temperature and pressure during skin penetration. By using feedback control, the system maintains optimal parameters for efficient drug delivery while simplifying the overall control strategy through closed-loop regulation rather than requiring complex open-loop control systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Improves drug delivery efficiency by forming a pressure difference for non-invasive skin penetration, enhancing the administration of drugs through the skin.
Implementation Method 1
Controlling the pressure difference of skin administration through the pressure control parameter and the temperature control parameter, wherein the pressure difference is the pressure difference for feeding the skin through the skin
Implementation Method 2
Controlling the direct drug delivery unit to generate a drug delivery temperature according to the temperature control parameter, wherein the drug delivery temperature, the first pressure and the second pressure form a pressure difference of the skin drug delivery
Data Source
AI summary
A drug delivery control method includes: S101: determining administration control parameter for skin administration, wherein the control parameter includes a first control parameter and a second control parameter, one of the first control parameter and the second control parameter is a pressure control parameter, and the other one of the first control parameter and the second control parameter is a temperature control parameter; and S102: controlling a pressure difference for the skin administration through the pressure control parameter and the temperature control parameter, the pressure difference being a pressure difference penetrating the skin for administration. The administration apparatus includes: a pressure assembly and a temperature assembly. The pressure assembly and the temperature assembly control the temperature and the pressure of the skin administration to form the pressure difference for the skin administration.