Transdermal Hydroalcoholic Gel for Testosterone and Glycemic Control
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Solution Overview
Problem
Current treatments for type-2 diabetes and related conditions, such as hypogonadism, often fail to effectively manage glycemic control and testosterone levels, leading to complications like erectile dysfunction and decreased quality of life.
Innovation Solution
A transdermal hydroalcoholic gel composition containing 0.01% to 15% testosterone, a penetration enhancing agent, a thickening agent, and lower alcohols, designed for percutaneous delivery to increase serum testosterone levels and improve glycemic control.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments for type-2 diabetes are used, then glycemic control is attempted, but testosterone levels and related symptoms (erective dysfunction, decreased libido) are not effectively managed
Solution Approach 1:
The patent applies multi-functionality by formulating a single transdermal gel composition that simultaneously addresses multiple conditions: type-2 diabetes management and hypogonadism treatment. The gel contains testosterone as the active ingredient, enabling it to restore testosterone levels while also improving glycemic control, thereby eliminating the need for separate treatments for each condition.
Solution Approach 2:
The patent merges the treatment of diabetes and hypogonadism into a single therapeutic formulation. By combining testosterone with appropriate excipients in a gel base, the invention creates one product that addresses both glycemic control and testosterone deficiency, simplifying the treatment regimen for patients with comorbid conditions.
2Quantity of substance
If testosterone replacement therapy is administered, then serum testosterone levels are raised, but the formulation must achieve effective percutaneous delivery through the skin
Solution Approach 1:
The patent uses an intermediary gel formulation to facilitate testosterone delivery through the skin. The gel matrix acts as a mediator that enables effective percutaneous absorption of testosterone, ensuring reliable delivery to the bloodstream while maintaining appropriate concentration levels.
Solution Approach 2:
The patent optimizes the formulation parameters of the gel, including the concentration of testosterone (0.01% to 15%), the type and amount of penetration enhancing agents, and the composition of the gel base. These parameter adjustments are designed to maximize percutaneous delivery efficiency while ensuring reliable serum testosterone elevation.
3Quantity of substance
If a transdermal gel formulation is used for testosterone delivery, then serum testosterone levels can be elevated, but the formulation complexity increases due to required penetration enhancing agents and specific composition ratios
Solution Approach 1:
The patent establishes specific parameter ranges for the gel formulation, including testosterone concentration (0.01% to 15%), penetration enhancing agent content (0.01% to 50%), and thickening agent amounts (0.01% to 50%). By defining these parameters, the invention simplifies the formulation process while ensuring effective percutaneous delivery.
Solution Approach 2:
The patent employs a composite gel formulation combining testosterone with penetration enhancing agents, thickening agents, and appropriate excipients. This composite approach integrates multiple functional components into a single cohesive formulation that achieves reliable testosterone delivery while managing formulation complexity through standardized composition ratios.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively raises serum testosterone concentrations to therapeutic levels, improving glycemic control and reducing symptoms associated with type-2 diabetes and hypogonadism, such as erectile dysfunction and decreased libido.
Implementation Method 1
a penetration enhancing agent
Data Source
AI summary
The present invention is generally related to a method of treating, preventing, or reducing the risk of developing type-2 diabetes, and, more particularly, is related to a method of administering a transdermal hydroalcoholic gel composition to treat or prevent type-2 diabetes and a method of administering a transdermal hydroalcoholic gel composition to increase glycemic control in a subject in need thereof.