Self-Dissolving Transdermal Matrices for Peptide Delivery
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Solution Overview
Problem
Traditional methods for delivering cosmetics and medicaments transdermally face challenges such as rapid degradation, limited delivery efficiency, and safety issues due to physical and chemical limitations, necessitating the development of more effective compositions and delivery systems.
Innovation Solution
The use of self-dissolving transdermal matrices composed of hydrophilic and hydrophobic polymers, which can be designed to dissolve at specific rates, incorporating active ingredients within the polymer matrix or encapsulated in microspheres/nanospheres for controlled release, and applied as films or patches that adhere well to the skin, even in moist conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional delivery systems are used, then ease of manufacture is maintained, but delivery efficiency and stability deteriorate due to rapid degradation and limited penetration
Solution Approach 1:
The patent employs composite polymer matrices combining hydrophilic and hydrophobic polymers to create a delivery system that simultaneously achieves high delivery efficiency and stability. The hydrophilic component enhances skin penetration and delivery efficiency, while the hydrophobic component provides structural stability and protects active ingredients from degradation, resolving the contradiction between productivity and reliability.
Solution Approach 2:
The patent utilizes encapsulation of active ingredients within microspheres or nanospheres nested inside the polymer matrix. This nested structure protects the active ingredients from degradation (improving stability) while enabling controlled release and enhanced penetration (improving delivery efficiency), thereby resolving the contradiction between reliability and productivity.
2Speed
If hydrophilic polymers are used to increase dissolution rate, then delivery speed improves, but structural integrity deteriorates causing premature tearing
Solution Approach 1:
The patent combines hydrophilic polymers (which provide fast dissolution rate) with hydrophobic polymers (which provide structural strength) in a composite matrix. The hydrophobic component maintains structural integrity and prevents premature tearing, while the hydrophilic component ensures rapid dissolution and fast delivery, resolving the contradiction between speed and strength.
Solution Approach 2:
The patent creates regions with different polymer compositions within the matrix - areas rich in hydrophilic polymers for rapid dissolution and areas rich in hydrophobic polymers for structural support. This local quality differentiation allows the material to simultaneously achieve fast dissolution rates and maintain structural integrity throughout the patch.
3Productivity
If active ingredients are incorporated into the polymer matrix, then delivery efficiency improves, but manufacturing complexity increases
Solution Approach 1:
The patent incorporates active ingredients into the polymer matrix during the manufacturing process itself, rather than requiring separate encapsulation or application steps. This preliminary incorporation simplifies manufacturing by combining multiple steps into one, while achieving high delivery efficiency through direct integration of the active ingredient into the delivery vehicle.
Solution Approach 2:
The patent merges the active ingredient incorporation step with the polymer matrix formation step, creating an integrated manufacturing process. By combining these operations, the patent reduces manufacturing complexity while maintaining high delivery efficiency through uniform distribution of active ingredients within the matrix.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables high flux and efficient delivery of active ingredients, with up to 100% delivery of the active agent, reducing the amount needed and improving skin penetration, while maintaining stability and safety, and can be combined with other delivery methods like microneedles or iontophoresis.
Implementation Method 1
The more hydrophilic, the faster (e.g. 1-20 seconds) the dissolution
Implementation Method 2
conversely, the more hydrophobic, the slower (minutes to hours to days) the dissolution
Implementation Method 3
Due to their extreme porosity the self-dissolving transdermal matrices prepared by these methods perform better in transdermal devices and show greater flux of active agent
Data Source
AI summary
The present invention relates to methods and compositions for the delivery of cosmetics and medicants. In some embodiments, the invention relates to compositions comprising both hydrophobic and hydrophilic polymers. In preferred embodiments, the invention relates to the delivery of peptides, small molecules and other bioactive compounds using the compositions and methods disclosed herein.