Transdermal Patch Adhesive Layer Delamination Prevention
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Solution Overview
Problem
Transdermal drug patches using non-volatile hydrocarbon oils with high viscosity experience delamination issues due to inadequate adhesion, leading to detachment of the support from the adhesive layer.
Innovation Solution
A patch composition including a drug with an amino group and specific functional groups bonded via a C1-C3 hydrocarbon chain, combined with a thermoplastic elastomer and non-volatile hydrocarbon oil with kinematic viscosity of 70 mm2/s or less at 40°C, where the oil content is limited to 230 parts per 100 parts of the elastomer, to enhance adhesion and prevent delamination.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If non-volatile hydrocarbon oil with high viscosity is used as a plasticizer for the thermoplastic elastomer, then adhesion is improved, but delamination occurs between the support and adhesive layer
Solution Approach 1:
The patent changes the viscosity parameter of the non-volatile hydrocarbon oil from high viscosity to 70 mm²/s or less at 40°C, and controls the amount to 230 parts by mass or less per 100 parts by mass of thermoplastic elastomer. This parameter optimization resolves the contradiction by achieving adequate adhesion while preventing delamination.
Solution Approach 2:
The patent creates a composite adhesive layer system comprising thermoplastic elastomer, non-volatile hydrocarbon oil with optimized viscosity, and specific drug molecules with amino groups and C1-C3 hydrocarbon chains. This composite formulation achieves both strong adhesion and delamination resistance through synergistic interactions between components.
2Strength
If non-volatile hydrocarbon oil is used as a plasticizer to achieve adequate adhesion, then adhesion strength increases, but the support peels from the adhesive layer
Solution Approach 1:
The patent optimizes the viscosity parameter of the non-volatile hydrocarbon oil to 70 mm²/s or less at 40°C and controls the plasticizer content at 230 parts by mass or less per 100 parts by mass of thermoplastic elastomer. This parameter control maintains layer bonding stability while achieving adequate adhesion strength.
3Strength
If high viscosity non-volatile hydrocarbon oil is used to enhance adhesion, then adhesive performance improves, but interlayer detachment occurs
Solution Approach 1:
The patent changes the viscosity parameter from high viscosity to 70 mm²/s or less at 40°C and controls the amount of non-volatile hydrocarbon oil at 230 parts by mass or less per 100 parts by mass of thermoplastic elastomer, achieving both good adhesive performance and precise interlayer bonding without detachment.
Data Source
AI summary
A patch includes an adhesive layer that includes (a) a drug, (b) a thermoplastic elastomer, and (c) non-volatile hydrocarbon oil having a kinematic viscosity of 60 mm2/s or less at 40° C. The (a) drug includes (i) an amino group that may have a substituent, and (ii) at least one functional group selected from the group consisting of an ester group, an amide group, an ether group, a thioether group, and an amino group different from the (i) amino group, all of which may have a substituent. The (a) has a structure, in which the (i) amino group, and the (ii) at least one functional group are bonded via a C1-C3 hydrocarbon chain. The number of hydroxyl groups per molecule of the (a) is 4 or less. An amount of the (c) is 230 parts by mass or less relative to 100 parts by mass of the (b).