Transdermal Patch Adhesive Triblock Elastomer Peeling
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Solution Overview
Problem
Transdermal patches with DMSO-containing adhesive layers tend to peel off when applied to areas that extend and contract during motion, such as joints, due to stress on the skin.
Innovation Solution
Incorporating a styrene-based thermoplastic elastomer with a triblock content of 35% to 65% in the adhesive layer, which maintains viscosity between 450 Pa·s to 900 Pa·s at 60°C and has a melt flow rate of 1.1 to 2 g/10 min, along with a backing material with high moisture permeability, to enhance adhesion and prevent peeling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a DMSO-containing adhesive layer is used in the transdermal patch, then drug solubility and adhesion are improved, but the patch peels off when applied to areas that extend and contract during motion
Solution Approach 1:
The patent changes the chemical composition parameters of the adhesive layer by incorporating a styrene-based thermoplastic elastomer with specific triblock content (35-65%). This parameter change modifies the adhesive's physical properties to accommodate skin movement while maintaining drug solubility and adhesion performance, thereby preventing peeling on movable areas.
Solution Approach 2:
The patent creates a composite adhesive layer by combining DMSO, drug substances, and styrene-based thermoplastic elastomer. This composite material leverages the excellent drug solubility of DMSO while the elastomer component provides mechanical flexibility and stress resistance, preventing peeling on areas that extend and contract during motion.
2Strength
If the adhesive layer has high viscosity to maintain adhesion, then bonding strength is improved, but the patch cannot accommodate skin extension and contraction
Solution Approach 1:
The patent optimizes the viscosity parameter of the adhesive layer to fall within 450-900 Pa·s at 60°C. This specific viscosity range allows the adhesive to maintain sufficient bonding strength while possessing enough flexibility to accommodate skin extension and contraction during motion, resolving the contradiction between strength and adaptability.
Solution Approach 2:
The styrene-based thermoplastic elastomer in the composite adhesive layer provides mechanical flexibility and stress resistance, allowing the adhesive to accommodate skin movement without losing bonding strength. The elastomer's elastic properties enable the adhesive to stretch and contract with the skin while maintaining adhesion.
3Stability of the object's composition
If the adhesive layer is made more flexible to accommodate skin motion, then peeling is prevented, but cohesive force and residue reduction are compromised
Solution Approach 1:
The patent optimizes the melt flow rate parameter to 1.1-2 g/10 min at 60°C, which balances flexibility and cohesive force. This parameter control ensures the adhesive remains flexible enough to prevent peeling on movable areas while maintaining sufficient cohesive strength to prevent excessive residue and maintain bonding integrity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The transdermal patch exhibits superior cohesive force, reducing residue and maintaining adhesion even on skin that extends and contracts, ensuring the patch remains in place without contaminating clothing.
Implementation Method 1
a styrene-based thermoplastic elastomer having a triblock content of 35% to 65% is blended in an adhesive layer
Implementation Method 2
the adhesive layer has a viscosity of 450 Pa·s to 900 Pa·s at 60°C and a melt flow rate of 1.1 to 2 g/10 min at 60°C
Data Source
AI summary
The present invention provides a transdermal patch comprising an adhesive layer on a backing, wherein the adhesive layer comprises a drug, DMSO, and an adhesive base, and the adhesive base comprises a styrene-based thermoplastic elastomer having a triblock content of 35% to 65%.