Transdermal Patch Base Odor Suppression via Copolymer
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Solution Overview
Problem
Conventional patch bases using L-menthyl glyceryl ether as a cooling agent still generate an unpleasant odor, despite efforts to replace L-menthol, due to the presence of gelatin and polyvinyl alcohol.
Innovation Solution
Incorporating a methyl acrylate/2-ethylhexyl acrylate copolymer into the patch base composition, with specific content ranges for gelatin, polyvinyl alcohol, and the copolymer, to inhibit the generation of unpleasant odors from these components while maintaining adhesive force.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If L-menthyl glyceryl ether is used as a cooling agent to replace L-menthol, then the irritating odor is reduced, but an unpleasant odor still generates from gelatin and polyvinyl alcohol
Solution Approach 1:
A methyl acrylate/2-ethylhexyl acrylate copolymer is introduced as an intermediary substance that masks or suppresses the unpleasant odor generated by gelatin and polyvinyl alcohol. The copolymer acts as a mediator between the base materials and the cooling agent, preventing the odor issue while maintaining the cooling effect.
Solution Approach 2:
The patch base is formulated as a composite material containing gelatin, polyvinyl alcohol, and methyl acrylate/2-ethylhexyl acrylate copolymer in specific proportions. This composite structure allows the materials to work together, where the copolymer component specifically addresses the odor issue while the gelatin and polyvinyl alcohol provide moisture retention and shape stability.
2Stability of the object's composition
If gelatin and polyvinyl alcohol are contained in the base to ensure high moisture content and shape retention, then excellent cohesiveness is achieved, but unpleasant odor is generated
Solution Approach 1:
The invention optimizes the concentration parameters of gelatin (1-10% by mass) and polyvinyl alcohol (0.1-5% by mass) within specific ranges. By controlling these parameters and introducing the copolymer, the system maintains the beneficial properties of moisture retention and shape stability while suppressing the odor through parameter optimization.
3Stability of the object's composition
If the base contains water soluble polymers for high moisture content, then excellent shape retention is ensured, but the adhesive force may be compromised when adding copolymer
Solution Approach 1:
The invention carefully controls the concentration parameters of all components: gelatin (1-10% by mass), polyvinyl alcohol (0.1-5% by mass), and methyl acrylate/2-ethylhexyl acrylate copolymer (0.1-10% by mass). This parameter optimization ensures that the adhesive force is maintained within the range of 10-500 g/cm² while preserving shape retention properties.
Data Source
AI summary
A patch base comprises gelatin, polyvinyl alcohol, a methyl acrylate/2-ethylhexyl acrylate copolymer, and L-menthyl glyceryl ether, wherein relative to the total mass of the base, the content of the gelatin is 1.5 to 6% by mass, the content of the polyvinyl alcohol is 0.5 to 8% by mass, and the content of the methyl acrylate/2-ethylhexyl acrylate copolymer is 0.5 to 13% by mass.