Transdermal Patch Drug Disposal Adsorbing Layer
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Solution Overview
Problem
Transdermal drug delivery patches often contain residual amounts of drugs that can be abused due to excess drug in the reservoir or adhesive, posing a risk for misuse and requiring safe disposal methods to reduce these residues.
Innovation Solution
A drug disposal device with an adsorbing layer, primarily composed of a hydrogel containing activated carbon, is used to sequester residual drugs from used transdermal patches, preventing back-extraction and facilitating safe disposal.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If excess drug is included in the transdermal patch reservoir or adhesive to facilitate transdermal delivery kinetics, then the appropriate dose can be delivered to the patient, but residual drug remains in the patch after use that is sufficient for abuse and misuse
Solution Approach 1:
The patent extracts the harmful residual drug from the transdermal patch by applying an adsorbent material (such as activated carbon or ion-exchange resin) that selectively binds and removes the drug from the patch adhesive or reservoir, thereby eliminating the abuse potential while maintaining the delivery performance
Solution Approach 2:
The patent introduces an intermediary adsorbent material between the residual drug and the environment, which acts as a mediator to capture and sequester the drug, preventing its recovery or abuse while allowing the patch to maintain its therapeutic function
2Duration of action of stationary object
If transdermal patches are designed for sustained drug delivery over several days, then repeated oral dosing is eliminated, but the patches contain significant residual drug that requires special disposal measures
Solution Approach 1:
The patent applies the discarding principle by designing a disposal system where the residual drug is recovered and neutralized through adsorption onto specialized materials, allowing safe disposal of the patch without environmental contamination or abuse risk, while the adsorbent can be disposed of with the patch
3Reliability
If transdermal patches use high concentrations of drug in the adhesive to achieve sustained delivery, then effective pain management is maintained, but the risk of misuse increases due to recoverable residual drug
Solution Approach 1:
The patent converts the harmful residual drug into a beneficial state by using adsorbent materials that irreversibly bind the drug, transforming the abuse-risk-containing residual drug into a neutralized form that cannot be recovered or misused, while the patch maintains its therapeutic reliability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively reduces the amount of residual drug in transdermal patches, minimizing the risk of abuse by adsorbing the drug and rendering it unavailable for misuse, ensuring safe and secure disposal.
Implementation Method 1
the adsorbing layer comprises a hydrogel produced from a homogeneous mixture of gel components including: (i) at least about 5% by weight activated carbon
Data Source
AI summary
Drug disposal devices and systems for reducing the amount of drug contained in a transdermal drug delivery patch are disclosed. The drug disposal devices contain an adsorbing substance, such as activated carbon, and are capable of adsorbing residual drug from the transdermal patch and preventing back-extraction of the drug. Also disclosed are methods of manufacturing the drug disposal devices and methods of using the drug disposal devices for reducing the amount of drug contained within a transdermal drug delivery patch.