Transdermal Patch Hydrophilic Polymer Water Absorption
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Solution Overview
Problem
Current transdermal preparations for arthritis treatment using non-steroidal anti-inflammatory drugs face challenges in achieving high and sustained drug permeation through the skin, leading to reduced efficacy and potential skin side effects, with existing solutions often resulting in peak drug delivery followed by decreased permeation and limited adhesion.
Innovation Solution
A transdermal preparation with a layered structure comprising a flexible backing layer, a hydrophobic adhesive layer to prevent water loss, a drug adhesive layer containing hydrophilic polymers like polyvinyl pyrrolidone for enhanced water absorption and drug solubility, and a release layer to protect the drug until application, ensuring continuous drug delivery and improved adhesion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a multi-layered structure with separate adhesive layers is used to improve adhesion, then adhesion is enhanced, but the structure becomes complex and production becomes difficult
Solution Approach 1:
The patent combines the adhesive layer and drug-containing layer into a single integrated layer, eliminating the need for separate adhesive layers while maintaining both adhesion and drug delivery functions. This simplifies the multi-layered structure and makes production easier while still achieving reliable skin adhesion and continuous drug permeation.
2Productivity
If permeation enhancers and high drug concentration are used to increase drug permeation, then drug delivery is improved, but skin side effects increase
Solution Approach 1:
The patent changes the physical and chemical parameters of the adhesive layer by incorporating hydrophilic polymer resins that can absorb water from the skin. This creates a hydrated environment that enhances drug solubility and permeation without requiring aggressive permeation enhancers, thereby maintaining high drug delivery while reducing skin irritation and side effects.
3Productivity
If drug concentration in the adhesive layer is increased to improve treatment efficacy, then drug delivery is enhanced, but adhesion performance deteriorates
Solution Approach 1:
The patent creates a composite adhesive layer that combines adhesive polymers with hydrophilic polymer resins capable of absorbing water from the skin. This composite structure allows high drug concentration to be maintained while the hydrophilic components provide skin hydration that enhances both adhesion and drug solubility, preventing the trade-off between drug loading and adhesion performance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables continuous high-concentration drug permeation through the skin for an extended period, minimizing skin side effects and maintaining optimal adhesion until the patch is detached, thereby enhancing treatment efficacy and patient comfort.
Implementation Method 1
a drug layer containing a non-steroidal anti-inflammatory drug, an adhesive material and a hydrophilic polymer material having a high solubility for the non-steroidal anti-inflammatory drug, wherein the hydrophilic polymer material comprises polyvinyl pyrrolidone
Implementation Method 2
enabling the hydrophobic drug of a high concentration to be continuously permeated into the skin
Data Source
Figure 1
AI summary
Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.