Transdermal Patch with Separated Active Agent Layer
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current topical delivery systems for pharmaceutically active agents, such as those used for drug addiction treatment, often mix the agents with adhesives, leading to incomplete dose delivery and unacceptable side effects.
Innovation Solution
A transdermal delivery system comprising an absorbent material with menthol, a compound for treating drug addiction, a carrier solvent, an absorbent polymer, and a surfactant, separated from the adhesive layer to ensure full contact with the skin.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If the pharmaceutically active agent is mixed with the adhesive in the patch, then the patch structure is simple and easy to manufacture, but the active agent is entrapped and cannot deliver the full dose to the skin
Solution Approach 1:
The patch is divided into separate functional layers: an adhesive layer for skin attachment and an absorbent material layer for active agent delivery. This segmentation prevents the active agent from being trapped in the adhesive while maintaining simple manufacturing through layer assembly.
Solution Approach 2:
The active agent is extracted from the adhesive matrix and placed in a separate absorbent material layer. This extraction ensures the active agent is not entrapped by the adhesive and can be delivered in full dose to the skin, while the adhesive layer maintains its structural function.
2Device complexity
If the active agent is mixed with the adhesive, then the patch structure is simplified, but side effects increase due to incomplete dose delivery and potential adhesive interaction
Solution Approach 1:
By separating the adhesive function from the active agent delivery function into distinct layers, the patch eliminates harmful interactions between adhesive and active agent, reducing side effects while maintaining structural simplicity through modular design.
Solution Approach 2:
Removing the active agent from the adhesive matrix eliminates potential harmful interactions and ensures complete dose delivery, thereby reducing side effects associated with incomplete delivery and adhesive interference.
3Ease of manufacture
If the active agent is mixed with the adhesive, then manufacturing is easier, but the full therapeutic effect is not achieved due to adhesive interference
Solution Approach 1:
The patch uses separate layers for adhesive and active agent delivery, ensuring the active agent is not interfered with by the adhesive, thereby maintaining full therapeutic effect while keeping manufacturing simple through layer assembly.
Solution Approach 2:
Extracting the active agent from the adhesive matrix eliminates adhesive interference, ensuring complete and reliable therapeutic effect while maintaining ease of manufacture through separate layer preparation and assembly.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This system provides effective, side-effect-free delivery of pharmaceutically active agents like psilocybin and cannabinoids, enhancing pain relief and reducing drug addiction symptoms by ensuring complete dose administration without adhesive interference.
Implementation Method 1
an absorbent polymer
Implementation Method 2
a surfactant
Implementation Method 3
an absorbent material including menthol
Data Source
AI summary
The present disclosure relates to compositions, including, transdermal delivery systems useful as topical analgesics including an effective amount of a compound (e.g., psilocybin) for treating drug addiction (e.g. opioid addiction) and menthol and optionally cannabinoids wherein the menthol component can be a stabilized menthol composition comprising menthol and at least one menthol stabilizer compound including undecylenic acid methyl ester, undecylenic acid or a salt of undecylenic acid.