Transdermal Supplement Formulation for Skin Protection
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Solution Overview
Problem
Current skincare products often fail to address the underlying causes of skin damage such as oxidative stress and glycation, and are not tailored to individual skin types, leading to inadequate protection and repair.
Innovation Solution
A transdermal supplementation method using a formulation comprising therapeutically effective amounts of 5-MTHF, P-5-P, human growth hormone or its analogues, and additional ingredients like cannabinoids, citicoline, and methylcobalamin, applied via topical or oral routes to enhance penetration and absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If topical skincare products are applied to address skin damage symptoms, then surface protection is improved, but underlying causes such as oxidative stress and glycation are not addressed
Solution Approach 1:
The invention segments the treatment approach by combining topical application (for surface delivery) with systemic supplementation through multiple administration routes (oral, transdermal, intravenous, intramuscular, subcutaneous). This segmentation allows different components to address different levels of skin damage - topical agents handle surface symptoms while internally administered supplements address underlying oxidative stress and glycation processes.
Solution Approach 2:
The patent introduces multiple intermediary substances including antioxidants (vitamins C, E, carotenoids), anti-glycation agents (aminoguanidine, beta-carboline derivatives), and cellular supplements (5-MTHF, P-5-P, melatonin) that mediate between the external environment and internal cellular processes. These intermediaries transfer protective effects from the surface to deeper tissue levels, bridging the gap between topical application and systemic treatment.
2Device complexity
If single-ingredient supplements are used, then simplicity is maintained, but synergistic benefits and penetration are insufficient
Solution Approach 1:
The invention merges multiple active ingredients into integrated formulations that work synergistically. The combination includes antioxidants (vitamins C, E, carotenoids, flavonoids), anti-glycation agents (aminoguanidine, beta-carboline derivatives), cellular supplements (5-MTHF, P-5-P, melatonin, coenzyme Q10), and growth factors (EGF, FGF, insulin-like growth factor). This merging creates a multi-functional system where each component enhances the others' effectiveness, providing both topical and systemic benefits simultaneously.
3Ease of manufacture
If skincare products are not tailored to individual skin types, then manufacturing complexity is reduced, but absorption and permeability needs are not met
Solution Approach 1:
The invention implements a dynamic approach to skincare by offering multiple administration routes (topical, oral, transdermal, intravenous, intramuscular, subcutaneous) that can be selected and combined based on individual skin type characteristics. The formulation includes variable concentrations of active ingredients that can be adjusted according to specific skin needs - such as higher antioxidant levels for oxidative stress-prone skin or enhanced anti-glycation agents for glycation-susceptible individuals.
Data Source
AI summary
A method and compositions of treatment using supplementation, comprising the step of applying a supplement formulation to a human subject via a selected administration route, the supplement formulation comprising therapeutically effective amounts of a hormone supplement, 5-MTHF, and P-5-P. The hormone supplement may comprise human growth hormone or a precursor or analogue thereof, and additional therapeutically-effective amounts of cannabinoids, citicholine, or methylcobalamin may be added.