Transfer Vessel Beveled Lip Centrifugal Sample Combining
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Solution Overview
Problem
Current methods for collecting, transporting, and analyzing small volume biological samples are inadequate in reducing sample degradation and loss, leading to invalid clinical results.
Innovation Solution
The use of transfer vessels with beveled lips and holding vessels that allow for gentle centrifugation to combine small volume fluid samples, reducing sample loss and contamination during analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of substance
If samples are transferred from collection vessels to analysis vessels using conventional methods, then the sample can be analyzed, but significant sample loss occurs during transfer
Solution Approach 1:
The patent introduces a transfer vessel as an intermediary component between collection vessels and analysis vessels. This transfer vessel includes a receiving portion that accepts samples from collection vessels and a dispensing portion that provides samples to analysis vessels, thereby minimizing direct transfer losses and improving sample utilization efficiency
2Quantity of substance
If the entire sample must be removed from collection vessels for analysis, then complete sample analysis is possible, but sample loss increases and sufficient sample for analysis cannot be maintained
Solution Approach 1:
The transfer vessel is segmented into distinct functional portions: a receiving portion for accepting samples from collection vessels and a dispensing portion for providing samples to analysis vessels. This segmentation allows the system to retain samples in the collection vessel while transferring only the necessary amount to analysis vessels, thereby maintaining sufficient sample volume for analysis while minimizing loss
3Reliability
If conventional transfer methods are used, then sample transfer can be performed, but sample degradation and contamination occur
Solution Approach 1:
The transfer vessel serves as a controlled intermediary environment that minimizes direct exposure of samples to potential contaminants during transfer. The vessel design includes features that protect sample integrity while enabling efficient transfer between collection and analysis vessels
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach effectively reduces sample loss and contamination, providing a more reliable and efficient method for analyzing small volume biological samples by combining samples in a transfer vessel, thereby increasing the sample volume available for analysis.
Implementation Method 1
holding vessels that allow for gentle centrifugation to combine small volume fluid samples
Data Source
AI summary
Devices, systems and methods for holding and transferring small volume fluid samples are disclosed. Holding vessels, including holding vessels having two or more internal compartments for holding small volume fluid samples, are disclosed. Transfer vessels for receiving small volume fluid samples from such holding vessels are disclosed. Transfer vessels for combining small volume fluid samples from such holding vessels are disclosed. Methods for providing small volume fluid samples for analysis with small loss of sample are disclosed. Methods for providing small volume fluid samples for analysis using automated sample analysis devices and systems, with small loss of sample, are disclosed.