Translating Frame Receptacle for Damage-Free Tissue Extraction
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Solution Overview
Problem
Existing methods for generating solidified biological tissue samples, such as coagulated blood samples, face challenges in safely and easily removing the samples from the receptacle without causing damage due to adherence to the receptacle walls, leading to ruined samples.
Innovation Solution
A modular receptacle design with a frame member that can be translated relative to a base member, allowing for a charge state and a discharge state, facilitating the safe removal of solidified samples by lifting them above the frame, combined with a vibration generating device for patterning and solidification, and a separation device for easy extraction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a conventional flat-based receptacle is used for solidifying tissue samples, then the sample can be contained during formation, but the sample adheres to the base and side walls making removal extremely difficult and often damaging
Solution Approach 1:
The receptacle is divided into two separable components: a base member and a frame member. This segmentation allows the frame member to be removed independently, creating a clean separation surface that prevents tissue sample adhesion and enables easy, damage-free removal of the solidified sample from the base member.
Solution Approach 2:
The frame member is designed to be movable relative to the base member, transitioning between an engaged position during solidification and a separated position for removal. This dynamic configuration allows the receptacle to adapt to different operational phases: containing the sample during formation, then facilitating easy removal after solidification.
2Ease of operation
If the frame member is made removable for easy sample extraction, then sample removal is simplified, but the device complexity increases
Solution Approach 1:
The receptacle is divided into two separable components: a base member and a frame member. This segmentation allows the frame member to be removed independently, creating a clean separation surface that prevents tissue sample adhesion and enables easy, damage-free removal of the solidified sample from the base member.
Solution Approach 2:
The frame member is designed to be movable relative to the base member, transitioning between an engaged position during solidification and a separated position for removal. This dynamic configuration allows the receptacle to adapt to different operational phases: containing the sample during formation, then facilitating easy removal after solidification.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The design enables reproducible, damage-free removal of solidified tissue samples, improving the scalability and efficiency of tissue sample production by reducing the risk of sample damage during extraction.
Implementation Method 1
wave-induced patterning for generating solid three-dimensional structures
Implementation Method 2
subjected to sound-induced morphogenesis (SIM) and allowed to coagulate
Implementation Method 3
The blood sample is provided in a flat-based receptacle, subjected to sound-induced morphogenesis (SIM) and allowed to coagulate to result in a solidified tissue construct
Data Source
Figure 1A
Figure 1B
Figure 1C
AI summary
The present invention concerns a receptacle (11) for forming a solidified biological tissue sample, the receptacle comprising a frame member (4) arranged around the periphery of a base member (3) such that said frame member (4) and said base member (3) can perform a translational movement in relation to one another, wherein the receptacle is designed to alter between a charge state and a discharge state. The receptacle may further comprise one or more interface members for operationally coupling the receptacle (11) to a vibration generating device. The invention also concerns a system comprising the receptacle (11) and a vibration generating device provided with a coupling interface, as well as a method for generating waves in a substance contained in said receptacle (11) and for generating a biological tissue construct using the receptacle (11) and/or said system.