Translucent In-Vivo Device Using Rare Earth Doped Fluorapatite
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Solution Overview
Problem
Existing in-vivo indwelling devices face challenges in biocompatibility, chemical stability, and translucency, with hydroxyapatite being non-translucent and glass provoking immune responses, limiting their use in applications like brain-machine interfaces and optical monitoring.
Innovation Solution
A translucent in-vivo indwelling device made from rare earth doped fluorapatite with high linear transmittance and low porosity, providing biocompatibility, strength, and chemical stability, allowing for both information input and output through light transmission.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hydroxyapatite is used as the in-vivo indwelling device material, then biocompatibility is improved, but translucency deteriorates (the material is not translucent)
Solution Approach 1:
The patent applies parameter changes by transitioning from hydroxyapatite to fluorapatite material composition, and by controlling density parameters (≥2.9 g/cm³) and porosity parameters (<0.2%) to achieve the desired balance between biocompatibility and translucency. This material parameter transformation resolves the contradiction by finding a material state that satisfies both requirements simultaneously.
Solution Approach 2:
The patent employs composite materials by creating a fluorapatite-based material with specific compositional ratios (Ca:F ratio between 2.9:1 and 3.1:1) and controlled density, effectively developing a new composite material system that combines the biocompatibility of apatite with the translucency required for optical applications.
2Illumination intensity
If glass is used as the in-vivo indwelling device material, then translucency is improved, but biocompatibility deteriorates (immune response is provoked)
Solution Approach 1:
The patent resolves this contradiction by changing the fundamental material parameter from glass to fluorapatite, which has inherent biocompatibility properties. The specific control of density (≥2.9 g/cm³) and porosity (<0.2%) parameters ensures that the fluorapatite maintains both biocompatibility and the required translucency for optical applications.
Solution Approach 2:
The patent applies local quality by ensuring the fluorapatite material has specific local properties: high density regions (≥2.9 g/cm³) provide structural integrity and biocompatibility, while controlled low porosity (<0.2%) regions maintain translucency. This localized optimization of material properties resolves the contradiction between biocompatibility and translucency.
3Illumination intensity
If the in-vivo indwelling device is made translucent, then light transmission is improved, but immune response increases
Solution Approach 1:
The patent resolves this contradiction by changing the material composition parameter from traditional translucent materials to fluorapatite, which inherently provides biocompatibility. The controlled density (≥2.9 g/cm³) and porosity (<0.2%) parameters ensure that the material achieves the required light transmission while maintaining immune compatibility in vivo.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device maintains long-term biocompatibility and translucency, enabling stable in-vivo monitoring and laser oscillation, facilitating information exchange and therapeutic applications without immune response, making it suitable for bone replacement and brain interface uses.
Implementation Method 1
a material of rare earth doped fluorapatite having at least a certain density can be used to construct a translucent in-vivo indwelling device that exhibits a low level of light scattering loss
Implementation Method 2
the rare earth doped fluorapatite undergoes laser oscillation
Implementation Method 3
by focusing an ultra short pulse laser on a specific part of the brain via a glass window, it is possible to observe the luminescence produced by the multiphoton absorption process of fluorescent proteins
Data Source
AI summary
A translucent in-vivo indwelling device with a translucent region including a rare earth doped fluorapatite.