Transplanted Kidney with Host Urinary Tract for Urine Excretion
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Solution Overview
Problem
Regenerated kidneys produced through regenerative medicine cannot maintain renal function for a long time due to the inability to excrete produced urine, leading to hydronephrosis.
Innovation Solution
A transplantation organ comprising a kidney, a ureter, and a urinary bladder, derived from a genetically-manipulated non-human animal such as a pig, with the ureter and urinary bladder from different species, allowing for the excretion of produced urine through peristalsis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a regenerated kidney is transplanted to produce urine, then urine production capability is improved, but the inability to excrete urine causes hydronephrosis and renal function cannot be maintained
Solution Approach 1:
The invention divides the urinary system into separate functional components: a transplanted kidney for urine production and a host urinary tract (ureter and bladder) for urine excretion. This segmentation allows the kidney to be replaced while maintaining the excretory function through the host's existing structures, preventing hydronephrosis by ensuring proper urine drainage.
2Ease of manufacture
If regenerative medicine is used to form a kidney from stem cells, then the ability to produce urine is achieved, but the lack of connected excretory structures prevents long-term function
Solution Approach 1:
The invention merges the regenerative medicine approach (transplanted kidney from stem cells) with the host's existing urinary tract structures. The transplanted kidney is connected to the host's ureter and bladder, combining the advantages of regenerative kidney formation with the reliability of the host's excretory system for long-term function maintenance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the production and excretion of urine, preventing hydronephrosis and maintaining renal function by connecting the transplanted kidney's urinary bladder with the host's ureter, thereby creating a functional urinary excretory tract.
Implementation Method 1
allowing for the excretion of produced urine through peristalsis
Data Source
AI summary
An organ for transplantation having a kidney, a ureter, and a urinary bladder and an organ structure in which a first ureter, a first urinary bladder, a second ureter and a second urinary bladder are sequentially connected to a kidney can produce urine and excrete the produced urine, and thus is useful for transplantation.