Trehalose Particulate Composition Emulsifying Stability Trade-off

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Solution Overview

Problem

Conventional particulate compositions containing crystalline trehalose dihydrate lack emulsifying ability, failing to effectively disperse oily substances in water, limiting their applications in fields such as foods and cosmetics.

Innovation Solution

A particulate composition with crystalline trehalose dihydrate is developed by preparing a saccharide solution with trehalose and maltose/maltotriose in specific ratios, followed by spray-drying and aging under controlled humidity to achieve a degree of crystallinity that enhances emulsifying ability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional crystalline trehalose dihydrate is used, then storage stability is improved, but emulsifying ability deteriorates

Engineering Contradiction:
Improvestorage stabilityVSAvoidemulsifying ability
Core Design Contradiction:
ReliabilityVSAdaptability or versatility

Solution Approach 1:

The invention creates a composite particulate composition containing both crystalline trehalose dihydrate and amorphous trehalose, along with maltose and/or maltotriose. This composite structure combines the storage stability of crystalline form with the emulsifying properties of amorphous form and other saccharides, resolving the contradiction between stability and functionality.

Inventive Principle:
Principle #40Composite materials

Solution Approach 2:

The invention applies local quality by maintaining different physical states (crystalline and amorphous) of trehalose within the same particulate composition. The crystalline portions provide stability while the amorphous portions provide emulsifying ability, allowing different regions of the material to fulfill different functional requirements.

Inventive Principle:
Principle #3Local quality

2Manufacturing precision

If trehalose purity is increased to 98% or higher, then product quality is improved, but emulsifying ability deteriorates

Engineering Contradiction:
Improvetrehalose purityVSAvoidemulsifying ability
Core Design Contradiction:
Manufacturing precisionVSAdaptability or versatility

Solution Approach 1:

The invention changes the purity parameter from conventional 98% or higher to 70-97%, and simultaneously introduces other saccharides (maltose and/or maltotriose) at 3-30%. This parameter modification enables the material to gain emulsifying ability while maintaining adequate trehalose content for stability.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

By creating a composite saccharide system rather than pure trehalose, the invention achieves both adequate purity (70-97%) and emulsifying ability through the synergistic combination of multiple saccharide components with different functional properties.

Inventive Principle:
Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The resulting composition exhibits improved emulsifying ability, allowing for effective dispersion of hydrophobic substances in water, expanding its applications in foods, cosmetics, and pharmaceuticals.

Implementation Method 1

pulverizing the resulting saccharide solution by a spray-drying method

Methodology Applied
Scientific EffectSpray-drying:

Implementation Method 2

converting a part of trehalose in an amorphous form into crystalline trehalose dihydrate by aging the resulting pulverized saccharide powder

Methodology Applied
Scientific EffectCrystallization: Crystallisation

Data Source

PatentUS11337910B2Particulate composition comprising crystalline alpha, alpha-trehalose dihydrate, its preparation and uses
Publication Date: 2022.05.24 NAGASE VIITA CO LTD
  • US11337910B2 patent drawing
  • US11337910B2 patent drawing
  • US11337910B2 patent drawing

AI summary

An object of the present invention is to provide a particulate composition containing crystalline α,α-trehalose dihydrate, having an advantageous emulsifying ability.The above object is solved by providing a particulate composition comprising crystalline α,α-trehalose dihydrate, which consists of particles containing α,α-trehalose and maltose and/or maltotriose, wherein said particulate composition contains α,α-trehalose in an amount of 70% by weight or higher but 90% by weight or lower, on a dry solid basis; and maltose and/or maltotriose in a total amount of 3% by weight or higher, on a dry solid basis; and has a degree of crystallinity for crystalline α,α-trehalose dihydrate of 25% or higher but less than 90%, when calculated based on its powder X-ray diffraction profile.