Seeded Trenbolone Acetate Crystallization for Defined Particle Size
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Solution Overview
Problem
Existing methods for preparing Trenbolone Acetate suffer from low yield, poor reproducibility, and difficulty in achieving a defined particle size distribution, leading to low-quality and inefficient production.
Innovation Solution
A process involving crystallization of Trenbolone Acetate using a seed with a defined particle size distribution, which includes seeding a solution of Trenbolone Acetate in a solvent, cooling to form a suspension, and filtering to achieve a specific particle size range, allowing for high yield and reproducible production.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional crystallization methods are used for Trenbolone Acetate preparation, then the process is simple to operate, but the particle size distribution is undefined and product quality is low
Solution Approach 1:
The patent applies preliminary action by introducing seeds with a predefined particle size distribution before the crystallization process. These seeds serve as nucleation sites that guide the crystal growth, ensuring the final product achieves the desired particle size distribution (D10: 15-40 μm, D50: 67-130 μm, D90: ≤350 μm) without requiring complex post-processing equipment.
2Manufacturing precision
If multi-step synthesis routes are used to improve chemical purity, then the purity increases, but the yield decreases and production efficiency deteriorates
Solution Approach 1:
The patent employs parameter changes by optimizing the crystallization conditions including temperature range (0°C to 30°C), solvent selection (isopropanol), and seeding parameters. These controlled parameter changes enable the simultaneous achievement of high chemical purity (>99.50%) and high molar yield (85-95%) in a single crystallization step, eliminating the need for multiple purification steps that would reduce productivity.
3Quantity of substance
If seed crystallization with defined particle size is implemented, then the solid density increases and active ingredient utilization improves, but the crystallization process becomes more complex
Solution Approach 1:
The patent applies local quality by using seeds with specific particle size characteristics (D50: 8-90 μm) to locally control the nucleation and growth process. This localized control at the seed level propagates through the entire crystallization process, resulting in a final product with enhanced solid density and defined particle size distribution, while keeping the overall process relatively simple.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process achieves a molar yield of 85-95% and high chemical purity (>99.50%), with a defined particle size distribution that enhances solid density and facilitates more efficient use of active ingredient per volume, improving the quality and efficiency of Trenbolone Acetate production.
Implementation Method 1
crystallization of Trenbolone Acetate by means of addition of a seed having a define median value (D50) of the particle size distribution
Implementation Method 2
seeding said solution with a Trenbolone Acetate seed
Implementation Method 3
cooling until the obtainment of a suspension
Implementation Method 4
cooling until the obtainment of a suspension
Data Source
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AI summary
Object of the present invention is related to a process for the preparation of Trenbolone Acetate of formula (I): having a median value (D50) of the particle size distribution comprised in the range from 50 µm to 80 µm, or from 60 µm to 90 µm, or from 90 µm to 250 µm, by means of addition of a seed having a median value (D50) of the particle size distribution comprised respectively in the range from 8 µm to 15 µm, or from 15 µm to 20 µm, or from 20 µm to 90 µm, to a solution of Trenbolone Acetate in a solvent.