1,2,4-Triazine Carboxamides for Selective Weed Control
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Solution Overview
Problem
Existing herbicides, such as 1,2,4-triazine-3,5-dione-6-carbonylcyclohexanediones and 1,2,4-triazine-3,5-dione-6-carbonylpyrazoles, often lack sufficient herbicidal activity and compatibility with crop plants, necessitating the development of more effective compounds for selective weed control.
Innovation Solution
The use of 1,2,4-triazine-3,5-dione-6-carboxamides, specifically those with varied substituents, which exhibit enhanced herbicidal activity and selective control of weeds without harming crops, are developed, including their salts and stereoisomers, which can be applied pre-sowing, pre-emergence, or post-emergence.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing herbicides (1,2,4-triazine-3,5-dione-6-carbonylcyclohexanediones and 1,2,4-triazine-3,5-dione-6-carbonylpyrazoles) are used, then herbicidal activity is achieved, but the activity is insufficient and compatibility with crop plants is poor
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of the herbicide compound from carbonylcyclohexanedione or carbonylpyrazole groups to carboxamide groups. This structural parameter change results in compounds with enhanced herbicidal activity and improved selectivity, reducing phytotoxicity to crop plants while maintaining effectiveness against weeds.
Solution Approach 2:
The patent employs local quality by introducing specific substituent patterns at defined positions (R1, R2, R3, R4) on the 1,2,4-triazine ring system. By carefully selecting substituents at these local positions, the compound achieves differentiated behavior: high activity against target weeds while being safe for specific crop plants, thus resolving the contradiction between herbicidal power and crop compatibility.
2Productivity
If broad-spectrum herbicidal activity is achieved, then control of difficult-to-control perennial weeds is improved, but selectivity with respect to crop plants may be compromised
Solution Approach 1:
The patent achieves both broad-spectrum weed control and crop selectivity through parameter changes in the molecular structure. The carboxamide functional group at position 6 of the 1,2,4-triazine ring, combined with specific substituent patterns, creates a compound that is effective against diverse weed species including perennials while maintaining safety for crop plants through selective metabolic pathways.
Solution Approach 2:
The patent utilizes composite material principles by combining the 1,2,4-triazine core structure with carboxamide functional groups and various substituent combinations. This composite molecular architecture integrates multiple functional elements that work together to provide both broad herbicidal spectrum and crop selectivity, resolving the contradiction between productivity and adaptability.
Data Source
AI summary
The invention describes 1,2,4-triazine-3,5-dione-6-carboxamides of general formula (I) as herbicides. In this formula (I) R1 and R2 represent radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen. Q represents a tetrazolyl, triazolyl or oxadiazolyl radical. Z and Y each represent oxygen or sulphur.