Triazine Moiety Intraocular Lens UV Absorption
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Solution Overview
Problem
Existing intraocular lens (IOL) compositions with UV-absorbing moieties, such as benzophenone, often require substantial increases in concentration to achieve adequate UV absorption, leading to alterations in physical properties that necessitate reformulation and recertification, while existing solutions fail to provide sufficient UV blocking at specific wavelengths without significant changes in IOL characteristics.
Innovation Solution
Incorporating a trisaryl-1,3,5-triazine moiety into the polymeric composition at low concentrations (0.10 to 0.20% by weight) to reduce UV radiation transmittance at 370 nm by 90% or less, maintaining the refractive index and water content similar to compositions without the UV-absorbing compound.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If the concentration of UV-absorbing monomer is increased to achieve adequate UV absorption, then UV transmittance is reduced, but the physical properties of the polymer (refractive index, hydrophilicity) are significantly altered
Solution Approach 1:
The patent changes the chemical structure parameter of the UV-absorbing moiety from conventional benzophenone to a triazine derivative with specific aromatic pi-electron system configuration. This structural parameter change enables superior UV absorption efficiency at lower concentrations, thereby reducing the amount needed while maintaining physical property stability.
Solution Approach 2:
The patent creates a composite polymeric composition by incorporating a specific UV-absorbing monomer (containing triazine moiety) into the IOL polymer matrix. This composite approach combines the UV-absorbing functionality with the biocompatible polymer structure, achieving both UV protection and maintained physical properties through synergistic material design.
2Object-affected harmful factors
If a substantial increase in UV-absorbing moiety concentration is used to reduce UV transmittance, then UV blocking is improved, but reformulation and recertification are required due to altered physical properties
Solution Approach 1:
The patent optimizes the concentration parameter of the UV-absorbing monomer to a specific low range (0.1-0.5 wt%), which achieves adequate UV blocking without causing significant changes to physical properties that would trigger regulatory recertification requirements.
3Object-affected harmful factors
If conventional UV-absorbing compounds are used, then UV absorption is provided, but adequate UV blocking at specific wavelengths requires concentrations that alter polymer characteristics
Solution Approach 1:
The patent changes the molecular structure parameter of the UV-absorbing compound to a triazine derivative with optimized aromatic pi-electron system, which increases the molar absorptivity and UV absorption efficiency per unit concentration, thereby reducing the required quantity.
Solution Approach 2:
The patent uses a small amount (low concentration) of the UV-absorbing monomer that is incorporated into the polymer structure during synthesis, creating a permanent UV-absorbing function without requiring large quantities of separate UV-absorbing additives.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively reduces UV transmittance at 370 nm without substantially altering the refractive index or water content of the IOL, ensuring the polymer's physical properties remain largely unchanged, thus avoiding the need for reformulation and recertification.
Implementation Method 1
Incorporating a trisaryl-1,3,5-triazine moiety into the polymeric composition at low concentrations (0.10 to 0.20% by weight) to reduce UV radiation transmittance at 370 nm by 90% or less
Data Source
Figure 1
AI summary
A method for reducing the transmittance of ultraviolet radiation through an intraocular lens to 10 % or less at 370 nm by (a) polymerizing a mixture comprising: at least one first monomer and a second monomer comprising a trisaryl-1,3,5-triazine moiety, (b) forming an optic portion from the copolymer wherein the second monomer is present in about 0.10 to about 0.20 percent by weight of the overall polymer and wherein the optic portion of the intraocular lens displays essentially the same physical properties such as, for example, refractive index as the optic portion of the intraocular lens formed from the polymerized mixture of (a) without the second monomer, but otherwise identical conditions. Additionally, a method for preventing the transmittance of at least 90% of ultraviolet radiation at 370 nm through a foldable intraocular lens comprising: (a) incorporating a monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety into at least one polymer and (b) forming the polymer into a material suitable for use as an intraocular lens, wherein the monomer comprising a 4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy moiety comprises 0.10 to 0.15 weight percent of the overall dry polymer.