Trigonelline Ester Encapsulation for Controlled Release
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Solution Overview
Problem
Functional chemical actives in personal care and beauty products are unstable under environmental conditions, leading to premature degradation, short shelf life, and inefficient release, necessitating costly packaging and posing challenges in controlled release and stability.
Innovation Solution
A two-stage triggerable composition using trigonelline esters encapsulated in a stimuli-sensitive polymer matrix, where the trigonelline ester is hydrolyzed upon exposure to an aqueous medium, allowing for controlled release of functional actives such as fragrances, antioxidants, and skin-repairing agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If functional chemical actives are used directly in products, then product functionality is achieved, but stability and shelf life deteriorate due to premature degradation under environmental conditions
Solution Approach 1:
The patent divides the delivery system into two distinct components: an encapsulation matrix that provides physical protection and a hydrolyzable ester bond that provides controlled release. This segmentation allows the active ingredient to be protected during storage while enabling predictable release when needed, resolving the contradiction between stability and shelf life.
Solution Approach 2:
The active ingredient is pre-modified by converting it to a hydrolyzable ester form before encapsulation. This preliminary chemical modification enables the ingredient to remain stable during storage while being primed for controlled release through subsequent hydrolysis, thereby extending shelf life without sacrificing functionality.
2Reliability
If functional chemical actives are stabilized through encapsulation, then stability is improved, but controlled release becomes difficult to achieve
Solution Approach 1:
The patent changes the chemical parameters of the active ingredient by converting it to a hydrolyzable ester, which fundamentally alters its release mechanism. This parameter change enables controlled release through hydrolysis kinetics rather than relying solely on physical encapsulation barriers, making controlled release achievable while maintaining stability.
Solution Approach 2:
The hydrolyzable ester bond acts as an intermediary between the encapsulation matrix and the active ingredient. It provides a predictable, controllable release mechanism that is independent of the encapsulation matrix properties, thereby enabling controlled release while the matrix continues to provide stability.
3Duration of action of stationary object
If proactive chemistry (ester forms) is used for stability, then shelf life is extended, but release efficiency deteriorates due to incomplete hydrolysis and waste
Solution Approach 1:
The hydrolyzable ester bond enables the active ingredient to self-release through hydrolysis when exposed to aqueous environments. This self-service mechanism eliminates the need for external enzymes or complex degradation processes, ensuring complete and efficient release of the active ingredient while maintaining extended shelf life during storage.
4Reliability
If high concentrations of active ingredients are used to ensure efficacy, then product effectiveness is improved, but side effects increase due to instability and degradation
Solution Approach 1:
The active ingredient is pre-protected through encapsulation and chemical modification to a hydrolyzable ester form. This preliminary protection prevents degradation during storage and transport, allowing the use of lower concentrations that are sufficient for efficacy once released, thereby reducing side effects associated with high concentrations and degradation products.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition stabilizes functional actives, preventing premature release and ensuring controlled, targeted delivery of active ingredients, enhancing product efficacy and reducing waste and side effects.
Implementation Method 1
a trigonelline ester of a functional active with at least one hydroxyl group configured to release the functional active through a hydrolysis reaction upon contact with an aqueous medium
Implementation Method 2
encapsulating it in pH-sensitive polymers and then releasing it at a later time by changing the solubility of the encapsulating matrix through a pH change
Data Source
AI summary
A triggerable composition for two-stage, controlled release of a functional active chemical includes a trigonelline ester of a functional active with at least one hydroxyl group configured to release the functional active through a hydrolysis reaction upon contact with an aqueous medium, and an encapsulation material for encapsulating the trigonelline ester including a functional active, the encapsulation material triggerable to release the trigonelline ester upon the occurrence of an environmental stimulus. In other aspects, a viscous liquid or an absorbent article includes a triggerable composition for two-stage, controlled release of a functional active chemical, the composition including a trigonelline ester of a functional active with at least one hydroxyl group configured to release the functional active through a hydrolysis reaction upon contact with an aqueous medium, and an encapsulation material for encapsulating the trigonelline ester including a functional active.