Synthetic Trihydroxy Androst-6-one for Tumor and Neuron Protection
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Solution Overview
Problem
Naturally occurring polyhydric sterones are difficult to purify and synthesize due to their low abundance and complex structures, limiting their applications despite their potential pharmaceutical benefits.
Innovation Solution
The development of 2β,3α,5α-trihydroxy-androst-6-one (YC-10), a novel polyhydric sterone with a simpler structure for easier synthesis, improved bioavailability, and reduced interaction with other substances, which maintains pharmacological effects such as anti-tumor and neuron-protective properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If naturally occurring polyhydric sterones are used, then important physiological functions such as antineoplastic and immunity enhancement effects are achieved, but purification procedures become complicated and time-consuming due to extremely low levels in plants
Solution Approach 1:
The patent creates a simplified copy of naturally occurring polyhydric sterones by removing complex side chains while retaining the core steroid nucleus and key hydroxyl groups. This synthetic analog (2β,3α,5α-trihydroxy-androst-6-one) replicates the essential pharmacological properties without the purification difficulties of natural extraction
Solution Approach 2:
The patent modifies molecular parameters by reducing molecular weight from naturally occurring compounds to the synthetic analog. This parameter change simplifies the molecular structure, making it easier to synthesize and purify while maintaining biological activity
2Reliability
If naturally occurring polyhydric sterones with complex structures are used, then inherent pharmaceutical properties are maintained, but synthesis becomes difficult or impossible
Solution Approach 1:
The patent extracts only the essential pharmacophore elements from complex naturally occurring sterones - specifically the steroid nucleus with hydroxyl groups at positions 2β, 3α, and 5α, and a ketone at position 6. By taking out only these critical features and removing complex side chains, the compound becomes synthesizable while retaining pharmaceutical activity
Solution Approach 2:
The patent segments the complex natural sterone structure into essential and non-essential parts. The core steroid nucleus with specific hydroxyl and ketone groups is retained as the essential segment, while complex side chains are removed as non-essential segments, enabling practical synthesis
3Stability of the object's composition
If polyhydric sterones with long side chains are used, then natural structure is preserved, but molecular weight increases and bioavailability decreases
Solution Approach 1:
The patent removes heavy side chains from naturally occurring sterones, extracting only the essential steroid nucleus with key functional groups. This extraction reduces molecular weight significantly while preserving the core structure responsible for biological activity and improved bioavailability
Data Source
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AI summary
The present invention discloses compound 2β,3α,5α-trihydroxy-androst-6-one, having the structure of formula (I). The present invention also discloses a plurality of methods for preparing the compound and a use of the compound.