Triple-Internal-Standard Glycan Assignment for Capillary Electrophoresis

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Solution Overview

Problem

Traditional LC or CE based GU experiments for glycan structure determination are time-consuming, costly, and prone to errors due to the need for multiple separate MOL standard ladder experiments, which introduce migration time shifts and overlap issues, increasing processing time and resource consumption.

Innovation Solution

A method involving the co-injection of a triple internal standard of three different maltooligosaccharide (MOL) oligomers, including two bracketing standards and one internal labeling standard, allows for the calculation of glucose units (GU) values directly from a single separation experiment, reducing the need for multiple ladder runs and minimizing overlap.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If multiple separate MOL standard ladder experiments are performed for GU calculation, then measurement precision is improved, but loss of time and productivity deteriorate

Engineering Contradiction:
ImproveGU value calculation precisionVSAvoidprocessing time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent combines the GU calculation standard ladder experiment with the glycan sample separation experiment into a single co-injection run. The MOL oligomers serve as internal standards within the same electrophoretic separation, eliminating the need for separate standard ladder experiments while maintaining measurement precision through co-migration time reference.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The MOL oligomers serve multiple functions simultaneously: they act as both the separation standard for GU calculation and as internal migration time references within the same experimental run. This multi-functionality allows a single experiment to fulfill both calibration and sample analysis requirements.

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Measurement precision

If multiple separate MOL standard ladder experiments are performed, then measurement precision is improved, but device complexity and experimental cost increase

Engineering Contradiction:
ImproveGU value calculation precisionVSAvoidexperimental complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent merges the standard preparation, injection, and separation steps into a single unified experiment. By co-injecting MOL oligomers with glycan samples, the system eliminates multiple experimental setups and reduces device operation complexity while maintaining the precision needed for GU calculation.

Inventive Principle:
Principle #5Merging (Combining)

3Measurement precision

If multiple ladder runs are performed to avoid overlap, then measurement precision is improved, but productivity and loss of time deteriorate

Engineering Contradiction:
Improvestructural assignment accuracyVSAvoidanalysis throughput
Core Design Contradiction:
Measurement precisionVSProductivity

Solution Approach 1:

The patent segments the MOL oligomers by degree of polymerization (DP) and assigns them to specific migration time regions. This segmentation allows different DP oligomers to serve as references for different glycan size ranges within the same run, enabling simultaneous analysis without peak overlap while maintaining structural assignment accuracy.

Inventive Principle:
Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach significantly reduces processing time, decreases experimental costs, and enhances accuracy by eliminating the need for multiple ladder runs and minimizing overlap, thereby improving the precision of glycan structure determination.

Implementation Method 1

separation techniques such as capillary electrophoresis or liquid chromatography

Methodology Applied
Scientific EffectCapillary electrophoresis: Capillary Electrophoresis

Implementation Method 2

The glycan and three different oligomers of MOL are separated over time

Methodology Applied
Scientific EffectElectrophoresis: Electrophoresis

Data Source

PatentEP3504548B1A triple-internal standard based glycan structural assignment method for capillary electrophoresis analysis of carbohydrates, system and computer program product
Publication Date: 2025.10.15 DH TECH DEVMENT PTE
  • EP3504548B1 patent drawingFigure 1
  • EP3504548B1 patent drawingFigure 2
  • EP3504548B1 patent drawingFigure 3

AI summary

A separation device receives a known or unknown glycan that is co- injected with three different oligomers maltooligosaccharide (MOL). A detector measures the separated glycan and the separated three different oligomers as intensity peaks that are a function of migration time. The migration times of a plurality of other oligomers of MOL are calculated from the migration times of the three different oligomers. Glucose unit (GU) values for the intensity peaks of the separated glycan are calculated by comparing their migration times to the calculated migration times of the plurality of other oligomers of MOL. The processor identifies the structure of the glycan by comparing the calculated GU values of the intensity peaks of the separated glycan to a database of GU values for known glycan structures.